57353-87-4

Upstream product

• 98-88-4 benzoyl chloride 
• 134-32-7 1-amino-naphthalene 
• 634-42-4 N-1-naphthalenyl-benzamide 

Downstream Products

• 50495-91-5 1-(N-[1]naphthyl-benzimidoyloxy)-[2]naphthoic acid methyl ester 
• 872789-70-3 1-(4-hydroxy-2-phenyl-benzo[h]quinolin-3-yl)-ethanone 
• 36547-38-3 1,3-diphenylbenzo[h]quinazoline 
• 21010-45-7 N-(2-Chlorethyl)-N-(1-naphthyl)-benzamid 
• 72788-07-9 4-morpholin-4-yl-pyridine-2-carboxylic acid benzoyl-naphthalen-1-yl-amide 
• 15926-84-8 4,6-Bis--isophthalsaeure-dimethylester 
• 57761-74-7 1-naphthalen-1-yl-5-phenyl-1H-tetrazole 
• 21419-52-3 2-phenyl-3H-benzo[h]quinazolin-4-one 
• 861563-47-5 N-[1]naphthyl-benzimidic acid-thioanhydride 
• 33555-17-8 2-phenyl-1H-benzo[g]indole 
• 1428326-97-9 4-methyl-N-(2-phenyl4-benzo[h]quinolinyl)benzenesulfonamide 

Relevant academic research and scientific papers

Micro-flow synthesis and structural analysis of sterically crowded diimine ligands with five aryl rings

Sterically crowded diimine ligands with five aryl rings were prepared in one step in good yields using a micro-flow technique. X-ray crystallographic analysis revealed the detailed structure of the bulky ligands. The nickel complexes prepared from the lig

α-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles

Imidoyl sulfoxonium ylides are presented for the first time as potential precursors to generate α-imino metal-carbene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl]2 (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step. This class of sulfur ylide is successfully obtained from imidoyl chloride and dimethylsulfoxonium methylide (23 new examples in 45-85% yield) or by imino group formation from the corresponding β-keto sulfoxonium ylides and anilines in the presence of TiCl4 as a Lewis acid (9 examples in 33-94% yield).

5-Imino-1,2,4-thiadiazoles: First small molecules As substrate competitive inhibitors of glycogen synthase kinase 3

Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important therapeutic target in severe unmet human diseases. GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders. As GSK-3 has the ability to phosphorylate primed substrates, small molecules able to bind to this site should be perfect drug candidates, able to partially block the activity of the enzyme over some specific substrates. Here, we report substituted 5-imino-1,2,4-thiadiazoles as the first small molecules able to inhibit GSK-3 in a substrate competitive manner. These compounds are cell permeable, able to decrease inflammatory activation and to selectively differentiate neural stem cells. Overall, 5-imino-1,2,4-thiadiazoles are presented here as new molecules able to decrease neuronal cell death and to increase endogenous neurogenesis blocking the GSK-3 substrate site

Preparation of 1,5-disubstituted tetrazoles under phase-transfer conditions

Imidoyl chlorides, obtained by common methods from a wide range of aromatic mono- and diamides, are smoothly converted to the corresponding tetrazoles in high yields by treatment with NaN3 under phase-transfer conditions.