36547-38-3Relevant academic research and scientific papers
Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions
Chen, Jinjin,Chang, Dan,Xiao, Fuhong,Deng, Guo-Jun
supporting information, p. 5459 - 5463 (2019/01/03)
A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C-H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two a
Preparation of Quinazolines via a 2+2+2 Annulation from Aryldiazonium Salts and Nitriles
Ramanathan, Mani,Liu, Shiuh-Tzung
, p. 8290 - 8295 (2017/08/14)
A (2+2+2) modular synthesis of multisubstituted quinazolines has been realized by the direct reaction of aryldiazonium salts with two equivalent of nitriles. Reaction of aryldiazonium salt with a nitrile provides the initial formation of a reactive nitrilium ion, which is attacked by another molecule of nitrile followed by electrophilic cyclization to deliver the desired product. Notable flexibility in the substitution patterns, readily available substrates, short reaction time, transition metal-free, and gram-scale synthesis are the advantages of this method.
Transition Metal-Free Visible Light-Driven Photoredox Oxidative Annulation of Arylamidines
Shen, Zi-Chao,Yang, Pan,Tang, Yu
, p. 309 - 317 (2016/01/15)
A fast catalytic synthesis of multisubstituted quinazolines from readily available amidines via visible light-mediated oxidative C(sp3)-C(sp2) bond formation has been established. This reaction is a metal-free oxidative coupling catalyzed by a photoredox organocatalyst. The protocol features low catalyst loading (1 mol %).
One-pot synthesis of quinazoline derivatives via [2+2+2] cascade annulation of diaryliodonium salts and two nitriles
Su, Xiang,Chen, Chao,Wang, Yong,Chen, Junjie,Lou, Zhenbang,Li, Ming
supporting information, p. 6752 - 6754 (2013/07/26)
An efficient one-pot approach to multiple substituted quinazolines with diaryliodonium salt 1, and two nitriles 2 has been presented. The reaction enables great flexibility of the substitution patterns on quinazolines and is applicable to two different nitriles to give a regio-selective product.
The reaction of tetralones with nitriles: A simple approach to the synthesis of new substituted benzo[h]quinazolines, benzo[f]quinazolines and dibenzo[a,i]phenanthridines
Herrera, Antonio,Martínez-Alvarez, Roberto,Chioua, Mourad,Chatt, Rachid,Chioua, Rachid,Sánchez, Angel,Almy, John
, p. 2799 - 2811 (2007/10/03)
The one-pot reaction of 1-tetralone with nitriles in the presence of triflic anhydride affords in good yields 2,4-disubstituted 5,6-dihydrobenzo[h] quinazolines, which oxidation with DDQ leads to the corresponding benzo[h]quinazolines. 2-Tetralone undergo
