57427-85-7

Basic information

• Product Name: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (E)-
• Synonyms: α-benzamidocinnamic acid;(E)-α-benzamidocinnamic acid;E-benzamidocinnamic acid;(Z)-α-(benzamido)cinnamic acid;(E)-2-benzoylaminocinnamic acid;α-benzoylamino-cis-cinnamic acid
• CAS NO: 57427-85-7
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.284
• Mol File: 57427-85-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (E)-(57427-85-7)
• EPA Substance Registry System: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (E)-(57427-85-7)

Safety Data

• Hazardous Substances Data: 57427-85-7(Hazardous Substances Data)

Upstream product

• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 71370-72-4 bi-4,4'-(4-benzyl-2-phenyl-Δ²-oxazolin-5-one) 
• 15732-43-1 (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone 
• 100-52-7 benzaldehyde 

Downstream Products

• 78007-47-3 trans-N-styryl-benzamide 
• 15732-43-1 (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 37002-52-1 N-benzoyl-D-phenylalanine 
• 26348-47-0 (Z)-2-benzamidocinnamic acid 
• 2566-22-5 DL-N-benzoylphenylalanine 

Relevant articles and documents

N-Acylphenylalanines and Related Compounds. A New Class of Oral Hypoglycemic Agents

N-Benzoyl-DL-phenylalanine (1) was found to possess hypoglycemic activity.A series of the analogues of compound 1 were prepared and evaluated for their blood glucose lowering activity.Both the steric effects of the phenylalanine moiety and the effects of variations in the acyl moiety were investigated.This study elucidated some of the structure-activity relationships and led to the development of N-(4-ethylbenzoyl)-D-phenylalanine (34), which was 50 times more potent than the initial compound 1.

2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL (BINAP). A NEW ATROPISOMERIC BIS(TRIARYL)PHOSPHINE. SYNTHESIS AND ITS USE IN THE Rh(I)-CATALYZED ASYMMETRIC HYDROGENATION OF α-(ACYLAMINO)ACRYLIC ACIDS

Racemic 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl has been synthesized from 2,2'-dihydroxy-1,1'-binaphthyl in two steps and resolved into optically pure (R)-(+) and (S)-(-) enantiomers by the use of (+)-di-μ-chlorobis dipalladium.This new axially dissymmetric bis(triaryl)phosphine serves as an excellent ligand for Rh(I)-catalyzed asymmetric hydrogenations of α-(acylamino)acrylic acids or esters.Factors controlling the enantioselectivity and mechanistic aspects are discussed on the basis of the 31P-NMR measurements.