57427-86-8Relevant articles and documents
Pharmaceutical composition and method of treating cancer
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Page/Page column 47, (2020/12/07)
Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.
An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives
Ahmed Arafa, Wael Abdelgayed,Abdel-Magied, Ahmed Fawzy
, p. 338 - 352 (2018/07/05)
An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-Arylidene-2-phenyloxazol-5(4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles. Formula parented.
An efficient and green synthesis of benzylidene-2-N-(carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4-triazine derivatives and their antibacterial activity evaluation
Rani, V. Anitha,Kumari, Y. Bharathi
, p. 5931 - 5934 (2015/02/19)
An efficient and green synthesis of (Z)-3-allkyl-5(benzylidene/substituted benzylidene)-2N-(carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4-triazine derivatives have been developed in good yields and tested for their antibacterial activities against Escherichia coli, Providencia aeruginosa, Pseudomonas azotogensis and Baccilus subtillis. Some of the synthesized compounds possess good activity against Escherichia coli and Baccilus subtillis compared to standard drug streptomycin.