57437-13-5

Basic information

• Product Name: 2-phenyl-3a,4,5,6,7,7a-hexahydro-benzooxazole
• Synonyms: 2-phenyl-3a,4,5,6,7,7a-hexahydro-benzooxazole
• CAS NO: 57437-13-5
• Molecular Weight: 201.268
• Mol File: 57437-13-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-phenyl-3a,4,5,6,7,7a-hexahydro-benzooxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-3a,4,5,6,7,7a-hexahydro-benzooxazole(57437-13-5)
• EPA Substance Registry System: 2-phenyl-3a,4,5,6,7,7a-hexahydro-benzooxazole(57437-13-5)

Safety Data

• Hazardous Substances Data: 57437-13-5(Hazardous Substances Data)

Upstream product

• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 825-60-5 benzimidic acid ethyl ester 
• 64-17-5 ethanol 
• 127-08-2 potassium acetate 
• 38898-70-3 cis-2-amino-cyclohexanol-⁽¹⁾ 
• 4714-50-5 7-benzoyl-7-aza-bicyclo[4.1.0]heptane 
• 108881-46-5 (+/-)-N-(cis-2-hydroxy-cyclohexyl)-thiobenzamide 
• 108881-46-5 (+/-)-N-(trans-2-hydroxy-cyclohexyl)-thiobenzamide 
• 110149-86-5 (+/-)-trans-1-benzoylamino-2-(toluene-4-sulfonyloxy)-cyclohexane 
• 141-52-6 sodium ethanolate 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 132984-53-3 (+/-)-(trans-2-benzoylamino-cyclohexyl)-dimethyl sulfonium ; iodide 
• 132984-53-3 (+/-)-(cis-2-benzoylamino-cyclohexyl)-dimethyl sulfonium ; iodide 
• 79102-43-5 trans-N-benzoyl-2-fluorocyclohexylamine 

Downstream Products

• 3721-20-8 N-(2-chlorocyclohexyl)benzamide 
• 77469-29-5 (+/-)-2-phenyl-(3ar,7at)-3a,4,5,6,7,7a-hexahydro-benzothiazole 
• 5450-83-9 trans-2-(N-phenylcarbonylamino)-1-cyclohexanol 
• 100608-74-0 (+/-)-thiobenzoic acid S-(trans-2-amino-cyclohexyl ester); hydrochloride 
• 7472-23-3 2-benzoyloxycyclohexanone 

Relevant articles and documents

"Orthogonal" Lewis Acids: Catalyzed Ring Opening and Rearrangement of Acylaziridines

-

Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N -Bz Aziridines to Allylic Amides

Herein a bimetallic radical redox-relay strategy is employed to generate alkyl radicals under mild conditions with titanium(III) catalysis and terminated via hydrogen atom transfer with cobalt(II) catalysis to enact base-free isomerizations of N-Bz aziridines to N-Bz allylic amides. This reaction provides an alternative strategy for the synthesis of allylic amides from alkenes via a three-step sequence to accomplish a formal transpositional allylic amination.

Synthesis of β-fluoroamines by Lewis base catalyzed hydrofluorination of aziridines

Lewis base catalysis promotes the in situ generation of amine-HF reagents from benzoyl fluoride and a non-nucleophilic alcohol. The hydrofluorination of aziridines to provide β-fluoroamines using this latent HF source is described. This protocol displays a broad scope with respect to aziridine substitution and N-protecting groups. Examples of regio- and diastereoselective ring opening to access medicinally relevant β-fluoroamine building blocks are presented.