5746-29-2

Basic information

• Product Name: 6-METHOXYPURINE RIBOSIDE
• Synonyms: 6-METHOXYPURINE RIBOSIDE;6-Methoxypurine ribonucleoside;6-Methoxypurine-9-riboside;9H-Purine, 6-methoxy-9-.beta.-D-ribofuranosyl-;Nsc 30306;Nsc30606;6-Methoxypurine-9-beta-D-riboside;6-O-Methylinosine
• CAS NO: 5746-29-2
• Molecular Formula: C₁₁H₁₄N₄O₅
• Molecular Weight: 282.25266
• Mol File: 5746-29-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 610.7°Cat760mmHg
• Flash Point: 323.1°C
• Appearance: /
• Density: 1.84g/cm³
• Vapor Pressure: 9.12E-16mmHg at 25°C
• Refractive Index: 1.773
• CAS DataBase Reference: 6-METHOXYPURINE RIBOSIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXYPURINE RIBOSIDE(5746-29-2)
• EPA Substance Registry System: 6-METHOXYPURINE RIBOSIDE(5746-29-2)

Safety Data

• Hazardous Substances Data: 5746-29-2(Hazardous Substances Data)

Usage

General Description

6-METHOXYPURINE RIBOSIDE is a purine nucleoside that consists of the purine base 6-methoxypurine and the sugar ribose. It is a naturally occurring compound found in certain plants and is also used in the synthesis of nucleic acids and coenzymes. This chemical has been studied for its potential pharmacological properties, including antiviral and anticancer activity. Research has shown that 6-METHOXYPURINE RIBOSIDE may have potential therapeutic applications for the treatment of viral infections and cancer. Additionally, it has been investigated as a potential neuroprotective agent and a modulator of immune responses. Overall, 6-METHOXYPURINE RIBOSIDE is a compound with diverse potential biological and medicinal properties.

InChI:InChI=1/C11H14N4O5/c1-19-10-6-9(12-3-13-10)15(4-14-6)11-8(18)7(17)5(2-16)20-11/h3-5,7-8,11,16-18H,2H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 60-29-7 diethyl ether 
• 67-64-1 acetone 
• 3181-38-2 O^2'_,O3'_,O5'-triacetyl-inosine 
• 81100-62-1 7-methylguanosine hydroiodide 
• 1074-89-1 6-methoxypurine 
• 3510-73-4 (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate 

Downstream Products

• 1074-89-1 6-methoxypurine 
• 18646-11-2 α-D-ribofuranosyl-1-phosphate 
• 58-63-9 Inosine 

Relevant articles and documents

Production, characterization and synthetic application of a purine nucleoside phosphorylase from Aeromonas hydrophila

Purine nucleoside phosphorylase (PNP) from Aeromonas hydrophila encoded by the deoD gene has been over-expressed in Escherichia coli, purified, characterized about its substrate specificity and used for the preparative synthesis of some 6-substituted purine-9-ribosides. Substrate specificity towards natural nucleosides showed that this PNP catalyzes the phosphorolysis of both 6-oxo- and 6-aminopurine (deoxy)ribonucleosides. A library of nucleoside analogues was synthesized and then submitted to enzymatic phosphorolysis as well. This assay revealed that 1-, 2-, 6- and 7-modified nucleosides are accepted as substrates, whereas 8-substituted nucleosides are not. A few transglycosylation reactions were carried out using 7-methylguanosine iodide (4) as a d-ribose donor and 6-substituted purines as acceptor. In particular, following this approach, 2- amino-6-chloropurine-9-riboside (2c), 6-methoxypurine- 9-riboside (2d) and 2-amino-6-(methylthio)purine- 9-riboside (2g) were synthesized in very high yield and purity.