9H-Purine, 6-methoxy-9-beta-D-ribofuranosyl-

Base Information

• Chemical Name: 9H-Purine, 6-methoxy-9-beta-D-ribofuranosyl-
• CAS No.: 5746-29-2
• Molecular Formula: C11H14 N4 O5
• Molecular Weight: 282.256
• NSC Number: 409169,30606
• Mol file: 5746-29-2.mol

Synonyms:6-Methoxypurine-9-riboside;9H-Purine, 6-methoxy-9-.beta.-D-ribofuranosyl-;6-Methoxypurine ribonucleoside;NSC30606;NSC-30606;NSC409169;NSC-409169

Chemical Property of 9H-Purine, 6-methoxy-9-beta-D-ribofuranosyl-

Chemical Property:

• Vapor Pressure: 9.12E-16mmHg at 25°C
• Boiling Point: 610.7°Cat760mmHg
• Flash Point: 323.1°C
• PSA: 122.75000
• Density: 1.84g/cm³
• LogP: -1.55360
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 282.09641956
• Heavy Atom Count: 20
• Complexity: 349

Purity/Quality:

97% ^*data from raw suppliers

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-methoxy-9H-purin-9-yl)tetrahydrofuran-3,4-diol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)O)O

Technology Process of 9H-Purine, 6-methoxy-9-beta-D-ribofuranosyl-

There total 4 articles about 9H-Purine, 6-methoxy-9-beta-D-ribofuranosyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

7-methylguanosine hydroiodide (81100-62-1) + 6-methoxypurine (1074-89-1) → 7-methylguanine (578-76-7) + 6-methoxypurine riboside (5746-29-2)

Guidance literature:

With recombinant purine nucleoside phosphorylase from Aeromonas hydrophila; at 20 ℃; pH=7.5; regioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1002/adsc.201100505

Reference yield:

methanol (67-56-1) + (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate (3510-73-4,179112-79-9) → 6-methoxypurine riboside (5746-29-2) + adenosine (58-61-7)

Guidance literature:

With ammonia; at 50 ℃; for 16h;

DOI:10.1021/jo061885l

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + methanol (67-56-1) + diethyl ether (60-29-7,927820-24-4) + acetone (67-64-1) + O2',O3',O5'-triacetyl-inosine (3181-38-2,7687-41-4,26289-76-9,28069-16-1,63248-71-5) → 7-methylinosine (33763-06-3) + 1-methylinosine (2140-73-0,55927-68-9) + 6-methoxypurine riboside (5746-29-2)

Guidance literature:

DOI:10.1021/ja00885a019

upstream raw materials:

diazomethane

methanol

diethyl ether

acetone

Downstream raw materials:

Inosine

6-methoxypurine

α-D-ribofuranosyl-1-phosphate