57492-47-4

Basic information

• Product Name: 1-Phenyl-2-(2-chlorophenyl)benzimidazole
• Synonyms: 1-Phenyl-2-(2-chlorophenyl)benzimidazole;2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole
• CAS NO: 57492-47-4
• Molecular Formula: C₁₉H₁₃ClN₂
• Molecular Weight: 304.77292
• Mol File: 57492-47-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Phenyl-2-(2-chlorophenyl)benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2-(2-chlorophenyl)benzimidazole(57492-47-4)
• EPA Substance Registry System: 1-Phenyl-2-(2-chlorophenyl)benzimidazole(57492-47-4)

Safety Data

• Hazardous Substances Data: 57492-47-4(Hazardous Substances Data)

Usage

Class

Benzimidazole derivatives.

Pharmaceutical potential

Anti-cancer, anti-inflammatory, anti-fungal, and anti-viral properties.

Specific application

Anti-inflammatory agent, potential in the treatment of breast cancer.

Current status

Further research needed to understand pharmacological properties and therapeutic uses.

Upstream product

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Downstream Products

• 201-71-8 benzimidazo<1,2-f>phenanthridine 
• 2622-67-5 1,2-diphenyl-1H-benzoimidazole 

Relevant articles and documents

Conventional and microwave-assisted synthesis of benzimidazole derivatives and their in vitro inhibition of human cyclooxygenase

A large series of 1,2-diaryl-benzimidazole and 2-aryl-1H-benzimidazole derivatives were synthesized with slight differences using both microwave irradiation and conventional heating methods. Usually higher yields and time reactions reduction were obtained

Methods of treating or preventing sleep apnea

This invention provides methods for the treatment or prevention of sleep apnea in a mammal which compris administering to a mammal in need thereof an effective amount of a substituted benzimidazole, or a pharmaceutically acceptable salt or solvate thereof.

Non-peptidyl tachykinin receptor antagonists

This invention provides novel substituted benzimidazoles of formula II which are useful as tachykinin receptor antagonists. This invention also provides methods for treating a condition associated with an excess of tachykinin which comprises administering to a mammal in need thereof one of a series of substituted benzimidazoles. This invention further provides pharmaceutical formulations comprising one or more of the substituted benzimidazoles of the present invention in association with pharmaceutical carriers, diluents, or excipients. A and Ra-Re are as defined in the description.