57495-92-8

Basic information

• Product Name: (+)-CIS-1(R),2(S)-1,2-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE
• Synonyms: (+)-CIS-1(R),2(S)-1,2-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE;(1R,2S)-cis-1,2,3,4-tetrahydro-1,2-naphthalenediol;1,2,3,4-Tetrahydro-1,2-naphthalenediol.;1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene;(1S)-Tetralin-1α,2β-diol;(1S)-1,2,3,4-Tetrahydronaphthalene-1α,2α-diol;(1S,2R)-Tetralin-1α,2α-diol;(1R)-Tetralin-1β,2β-diol
• CAS NO: 57495-92-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 57495-92-8.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 308.4°Cat760mmHg
• Flash Point: 151.7°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.000295mmHg at 25°C
• Refractive Index: 1.627
• PKA: 13.81±0.40(Predicted)
• CAS DataBase Reference: (+)-CIS-1(R),2(S)-1,2-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-CIS-1(R),2(S)-1,2-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE(57495-92-8)
• EPA Substance Registry System: (+)-CIS-1(R),2(S)-1,2-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE(57495-92-8)

Safety Data

• Hazardous Substances Data: 57495-92-8(Hazardous Substances Data)

Usage

General Description

(+)-CIS-1(R),2(S)-1,2-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE, also known as cis-1,2-Dihydroxy-1,2,3,4-tetrahydronaphthalene, is a synthetic organic compound with a chemical formula C10H14O2. It is a stereochemically defined isomer of 1,2-dihydroxytetralin. This chemical is used in the pharmaceutical industry for the synthesis of various drugs and has shown potential as an antiviral agent. It is also used as a chiral building block in organic synthesis and as a ligand in asymmetric catalysis. The compound has attracted interest in the scientific community for its potential applications in medicinal chemistry and drug development.

InChI:InChI=1/C10H12O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-4,9-12H,5-6H2

Upstream product

• 75-91-2 tert.-butylhydroperoxide 
• 447-53-0 1,2-Dihydronaphthalene 
• 2461-34-9 1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 2461-34-9 (1R,2S)-1,2-epoxy-3,4-dihydronaphthalene 
• 51268-88-3 (1R,2S)-1,2-dihydronaphthalene-1,2-diol 
• 174814-12-1 (+)-cis-(1R,2S)-dihydroxy-1,2-dihydro-7-bromonaphthalene 
• 18672-77-0 2-acetoxy-3,4-dihydronaphthalen-1(2H)-one 
• 667894-33-9 1,2,3,4-tetrahydronaphthalene-1,2-diyl diacetate 
• 2018-87-3 1,2-dibromo-1,2,3,4-tetrahydro-naphthalene 
• 64-19-7 acetic acid 
• 2018-87-3 (+/-)-trans-1,2-dibromo-1,2,3,4-tetrahydronaphthalene 
• 14211-53-1 trans-naphthalene-1,2,3,4-tetrahydro-1,2-diol 
• 771-16-4 cis-1,2-dihydroxy-1,2-dihydronaphthalene 

Downstream Products

• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 89920-57-0 (1S,2R)-cis-1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene 
• 25040-17-9 methyl 3-[2-(methoxycarbonyl)phenyl]propionate 
• 776-79-4 2-(2-carboxyethyl)benzoic acid 
• 27916-44-5 3-(2-formylphenyl)propanoic acid 
• 14807-28-4 2-(3-oxopropyl)benzaldehyde 
• 54311-89-6 2-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine 
• 1346228-96-3 (1R,2R)-1,2-bis(benzyloxy)-1,2,3,4-tetrahydronaphthalene 
• 1346229-04-6 benzyl (1R,2R)-2-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate 
• 17180-88-0 (1R,2S)-(+)-naphthalene 1,2-oxide 
• 17180-88-0 (-)-(1S,2R)-naphthalene 1,2-oxide 
• 7480-36-6 (+/-)-cis-1-amino-2-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 426262-25-1 (1S,2S)-2-p-toluenesulphonyloxy-1-azido-1,2,3,4-tetrahydronaphthalene 
• 460740-17-4 (2S)-2-p-toluenesulphonyloxy-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Enantioselective, Stereoconvergent Resolution Copolymerization of Racemic cis-Internal Epoxides and Anhydrides

Unprecedented enantioselective resolution copolymerization of racemic cis-internal epoxides and anhydrides was mediated by dinuclear aluminum complexes with multiple chirality, affording optically active polyesters with two contiguous stereogenic centers, and the unreacted substrates in good enantioselectivity. Unexpected stereoconvergence is observed in this resolution copolymerization, where the selectivity factor for the enantioselective formation of copolymer significantly exceeds the kinetic resolution coefficient based on the unreacted epoxide at various conversions. Catalytic activity and copolymer enantioselectivity are strongly influenced by the phenolate ortho-substituents of the ligand set, as well as the axial linker and its chirality. An enantiopure binaphthol-linked bimetallic AlIII complex allows stereoconvergent access to the stereoregular semi-crystalline polyesters and a concomitant kinetic resolution of the epoxide substrates.

A de novo synthetic method to the access of N-substituted benzazepines

A novel, convenient procedure has been described for the construction of fluorine-containing benzazepines. The synthetic protocol starting from readily available dihydronaphthalene regioisomers is based on oxidative ring olefin bond cleavage followed by r

Oxidative β-Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins

β-Halohydrins bearing transformable halo- and hydroxyl groups, are easily converted into various valuable blocks in organic and pharmaceutical synthesis. A diastereoselective β-halogenation of benzylic alcohols was achieved under simple and low-cost conditions, which provided a direct synthesis of β-halohydrins. The simple reaction conditions, easily available reagents, high diastereoselectivities, and additional oxidant-free make this reaction very attractive and practical.