57538-75-7

Upstream product

• 171081-14-4 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridate 
• 171081-16-6 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridate 
• 162611-40-7 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite 
• 171081-10-0 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridite 
• 171081-12-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] O-(2-cyanoethyl) phosphorofluoridite 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 153413-66-2 O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(4-nitrophenyl) N,N-diisopropylphosphoramidite 

Relevant academic research and scientific papers

Synthesis of phosphorofluoridates and phosphorofluoridothioates via the phosphoramidite approach

We present a very efficient synthetic procedure leading to the phosphorofluoridates RO-P(O)(OH)F 1 or phosphorofluoridothioates RO-P(S)(OH)F 2, which is based on the intermediary of fluorophosphoramidites (RO)P(F)N iPr2 5 [R = 9-(hyd

Novel phosphitylating reagents containing a phosphorus-fluorine bond and their application in efficient synthesis of phosphorofluoridates and phosphorofluoridothionates

Novel phosphitylating reagents containing a P-F bond are obtained in excellent yield from commercial materials. They react with alcohols at 20 °C in neutral solvents in the presence of tetrazole, chlorotrimethylsilane or benzoyl chloride to give the inter

First Synthesis of Nucleosidyl Phosphorofluoridothioates and a Convenient Synthesis of Nucleosidyl Phosphorofluoridates

The first synthesis of 3'- or 5'-nucleosidyl phosphorofluoridothioates RO-P(S)(OH)F have been accomplished via nucleosidyl phosphoramidofluoridates RO-P(NPr12)F.An analogous convenient procedure has been employed to prepare 3'- or 5'-nucleosidy