57543-02-9

Basic information

• Product Name: 1-(3,4-dimethoxyphenyl)-3-phenyl-propan-2-one
• Synonyms: 1-(3,4-dimethoxyphenyl)-3-phenyl-propan-2-one
• CAS NO: 57543-02-9
• Molecular Weight: 270.328
• Mol File: 57543-02-9.mol

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dimethoxyphenyl)-3-phenyl-propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxyphenyl)-3-phenyl-propan-2-one(57543-02-9)
• EPA Substance Registry System: 1-(3,4-dimethoxyphenyl)-3-phenyl-propan-2-one(57543-02-9)

Safety Data

• Hazardous Substances Data: 57543-02-9(Hazardous Substances Data)

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 155955-78-5 3,4-dimethoxyphenylacetic acid N,O-dimethylhydroxyamide 
• 6921-34-2 benzylmagnesium chloride 
• 101-97-3 Ethyl 2-phenylethanoate 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 1589-82-8 phenylmagnesium bromide 
• 57543-01-8 α-phenacetyl-3,4-dimethoxyphenylacetonitrile 
• 93081-16-4 2-(3,4-dimethoxyphenyl)-3-oxo-4-phenylbutyramide 

Downstream Products

• 57543-05-2 3-benzyl-6,7-dimethoxy-3,4-dihydroisoquinoline 
• 57543-04-1 N-[1-benzyl-2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 118673-86-2 1-<1-(3,4-dimethoxyphenyl)-3-phenyl-2-propyl>-4-methylpiperazine 
• 93081-23-3 N-methyl-1-(3,4-dimethoxyphenyl)-3-phenyl-2-propylamine 
• 93081-21-1 1-(3,4-dimethoxyphenyl)-3-phenyl-2-propyl chloride 
• 321394-50-7 4-benzyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 321394-44-9 2-[1-benzyl-2-(3,4-dimethoxy-phenyl)-ethylamino]-1-phenyl-ethanol 
• 57543-03-0 1-(3,4-dimethoxyphenyl)-3-phenyl-propan-2-amine 
• 93081-20-0 1-(3,4-dimethoxyphenyl)-3-phenylpropan-2-ol 

Relevant articles and documents

Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.

NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I) wherein R1, R2 R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds in the treatment of the hepatitis B virus.

Two general routes to 1,4-disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines.

[structure] Two general routes to 1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepines are described. Both routes utilize an appropriately functionalized phenethylamino alcohol as the penultimate intermediate: the first route makes use of the reductive amination of a benzyl alkyl ketone with alpha-(aminomethyl)benzyl alcohol, while the second route utilizes the addition of a Grignard reagent to the oxazolidine derived from a substitued phenylacetaldehyde and alpha-(methylaminomethyl)benzyl alcohol. In all cases studied, the cis-1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepine was obtained as the major product.

New structural analogs of papaverine: 3 benzyl 6,7 dimethoxy (di and tetrahydro) isoquinolines

Syntheses of 3 benzyl 3,4 dihydroisoquinolines by cyclisation of a N acyl α benzylhomoveratrylamine by means of polyphosphoric acid ester, in boiling toluene, gave yields between 60 and 90%. While the hydrogenation of these dihydroisoquinolines to tetrahydroisoquinolines with an alkaline borohydride gave satisfactory result, their dehydrogenation into isoquinolines could not be accomplished. Pharmacological properties of the hydrobromides or hydrochlorides of the bases of the two series of the aforementioned 3 benzylisoquinolines and comparison of their activities with those of papaverine and the analogues 1 and 4 benzylisoquinolines are reported.