57543-03-0

Upstream product

• 93081-16-4 2-(3,4-dimethoxyphenyl)-3-oxo-4-phenylbutyramide 
• 101-97-3 Ethyl 2-phenylethanoate 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 155955-78-5 3,4-dimethoxyphenylacetic acid N,O-dimethylhydroxyamide 
• 57543-01-8 α-phenacetyl-3,4-dimethoxyphenylacetonitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 57543-02-9 1-(3,4-dimethoxyphenyl)-3-phenyl-propan-2-one 

Downstream Products

• 57543-04-1 N-[1-benzyl-2-(3,4-dimethoxyphenyl)ethyl]formamide 
• 57543-05-2 3-benzyl-6,7-dimethoxy-3,4-dihydroisoquinoline 

Relevant academic research and scientific papers

Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.

NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I) wherein R1, R2 R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds in the treatment of the hepatitis B virus.

New structural analogs of papaverine: 3 benzyl 6,7 dimethoxy (di and tetrahydro) isoquinolines

Syntheses of 3 benzyl 3,4 dihydroisoquinolines by cyclisation of a N acyl α benzylhomoveratrylamine by means of polyphosphoric acid ester, in boiling toluene, gave yields between 60 and 90%. While the hydrogenation of these dihydroisoquinolines to tetrahydroisoquinolines with an alkaline borohydride gave satisfactory result, their dehydrogenation into isoquinolines could not be accomplished. Pharmacological properties of the hydrobromides or hydrochlorides of the bases of the two series of the aforementioned 3 benzylisoquinolines and comparison of their activities with those of papaverine and the analogues 1 and 4 benzylisoquinolines are reported.