575452-35-6

Basic information

• Product Name: (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester
• Synonyms: (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester
• CAS NO: 575452-35-6
• Molecular Formula: C12H21NO4
• Molecular Weight: 243.29944
• Mol File: 575452-35-6.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• Density: 1.100
• CAS DataBase Reference: (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester(575452-35-6)
• EPA Substance Registry System: (2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester(575452-35-6)

Safety Data

• Hazardous Substances Data: 575452-35-6(Hazardous Substances Data)

Usage

General Description

(2R)-1,2-Pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester, also known as piracetam, is a chemical compound that belongs to the class of nootropic drugs, which are substances that enhance cognitive function and memory. Piracetam is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and is commonly used to improve memory, enhance learning, and increase focus and concentration. It is believed to work by increasing the activity of certain neurotransmitters in the brain, leading to improved cognitive function. Piracetam is also being investigated for its potential neuroprotective and mood-enhancing effects, and is commonly used as a study aid and cognitive enhancer.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 33305-75-8 L-proline ethyl ester monohydrochloride 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 64-17-5 ethanol 
• 5817-26-5 ethyl (2S)-pyrrolidine-2-carboxylate 
• 161362-39-6 ethyl 6-ethoxy-1,2-oxazinane-3-carboxylate 
• 14660-52-7 ethyl 5-bromovalerate 
• 144978-12-1 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate 
• 575452-53-8 (+)-ethyl (3R,6S)-6-[(R)-1-phenylbutoxy]-1,2-oxazinane-3-carboxylate 
• 575452-52-7 (+)-ethyl (6S)-6-[(R)-1-phenylbutoxy]-5,6-dihydro-4H-1,2-oxazine-3-carboxylate 
• 73472-94-3 ethyl 3-bromo-2-(hydroxyimino)propanoate 
• 96163-72-3 ethyl proline hydrochloride 
• 89896-39-9 ethyl 5-azidovalerate 
• 131477-20-8 ethyl pyrrolidine-2-carboxylate hydro chloride 

Downstream Products

• 1621435-37-7 tert-butyl 2-(((2S,3R)-1,3-bis(benzyloxy)-1-oxobutan-2-yl)carbamoyl)-2-(1-hydroxyethyl)pyrrolidine-1-carboxylate 
• 1621435-38-8 tert-butyl 2-((2S,3R)-1,3-bis(benzyloxy)-1-oxobutan-2-yl)-1-methyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621435-94-6 tert-butyl 2-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-methyl-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1621436-01-8 tert-butyl 2-(((2S,3R)-3-(benzyloxy)-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)carbamoyl)-2-(1-hydroxyethyl)pyrrolidine-1-carboxylate 
• 1621436-02-9 tert-butyl 2-((2S,3R)-3-(benzyloxy)-1-oxo-1-(pyrrolidin-1-yl)butan-2-yl)-1-methyl-3-oxo-2.5-diazaspiro[3.4]octane-5-carboxylate 
• 33305-75-8 L-proline ethyl ester monohydrochloride 
• 173690-69-2 tert-butyl 2-(2-cyanoacetyl)pyrrolidine-1-carboxylate 
• 1621482-38-9 1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)pyrrolidine-1,2-dicarboxylate 
• 1194030-71-1 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 1621435-28-6 tert-butyl 2-((2S, 3R)-1, 3-bis (benzyloxy)-1-oxobutan-2-yl)-1-oxo-2, 5-diazaspiro [3.4] octane-5-carboxylate 
• 1621435-13-9 tert-butyl 2-(((2S, 3R)-1, 3-bis (benzyloxy)-1-oxobutan-2-yl) carbamoyl)-2-(hydroxymethyl) pyrrolidine-1-carboxylate 

Relevant articles and documents

ANTIVIRAL COMPOUNDS

The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

A (1 R, 3 S) -3 - amino-cyclopentanol hydrochloride preparation method (by machine translation)

The invention discloses a (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride of the preparation method, the method using chiral carboxylic acid with hydroxylamine to form the amide as chiral source, in copper catalyzed oxidation in the reaction system to rapidly obtain a chiral Diels - alder reaction product, after passes through the reduction reaction and alkaline deprotection reaction, and acidified after reaction to obtain the target product. Chiral inducing reagent chiral carboxylic acid by simple acidification, extraction processing can be reclaimed and reused. This kind of (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride preparation method has high operation safety and high selectivity, raw materials are easy, and the cost is low, the reaction time is short and simple process flow and the like. (by machine translation)

N-Heterocyclic Carbene Iron(III) Porphyrin-Catalyzed Intramolecular C(sp3)–H Amination of Alkyl Azides

Metal-catalyzed intramolecular C?H amination of alkyl azides constitutes an appealing approach to alicyclic amines; challenges remain in broadening substrate scope, enhancing regioselectivity, and applying the method to natural product synthesis. Herein we report an iron(III) porphyrin bearing axial N-heterocyclic carbene ligands which catalyzes the intramolecular C(sp3)–H amination of a wide variety of alkyl azides under microwave-assisted and thermal conditions, resulting in selective amination of tertiary, benzylic, allylic, secondary, and primary C?H bonds with up to 95 % yield. 14 out of 17 substrates were cyclized selectively at C4 to give pyrrolidines. The regioselectivity at C4 or C5 could be tuned by modifying the reactivity of the C5–H bond. Mechanistic studies revealed a concerted or a fast re-bound mechanism for the amination reaction. The reaction has been applied to the syntheses of tropane, nicotine, cis-octahydroindole, and leelamine derivatives.