575457-75-9

Upstream product

• 3601-36-3 methyl 2,3,6-tri-O-benzoyl-α-D-galactopyranoside 
• 3396-99-4 methyl α-D-galactopyranoside 
• 10257-28-0 D-Galactose 
• 575457-73-7 C₂₄H₂₁N₅O₈ 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 74593-34-3 methyl 4-azido-2,3,6-tri-O-benzoyl-4-deoxy-α-D-glucopyranoside 
• 79580-70-4 Methyl 2,3,6-tri-O-benzoyl-4-O-trifluoromethanesulfonyl-α-D-galactopyranoside 
• 575457-72-6 C₂₆H₂₃N₅O₉ 

Relevant academic research and scientific papers

Total synthesis method for xinaomycin

The invention belongs to the technical field of pharmaceutical chemistry and organic synthesis, and aims to provide a chemical total synthesis method for xinaomycin. The method comprises the steps of:using D-galactose and the like as raw materials, firstly carrying out 8 steps of reactions to obtain a compound 14, then performing condensation on the compound 14 and uracil to obtain a compound 15,performing 4 steps of reactions to obtain a compound 19, performing condensation on the compound 19 and a compound 6 to obtain a compound 20, and finally removing an ester protecting group and a Cbzprotecting group in turn, so as to obtain the natural product xinaomycin. The total synthesis method of the present invention is a method for synthesizing the natural product xinaomycin for the firsttime. The total synthesis method has the advantages of high product purity, low cost, simple operation and the like.

An efficient synthesis of gougerotin and related analogues using solid- and solution-phase methodology

(Chemical Equation Presented) The first solid-phase synthesis of the natural product gougerotin has been accomplished. The synthetic route is versatile and allows for diversification at position C-4 of the heterocycle, C-6′ of the sugar ring, and both residues of the peptidic moiety at N-4′ in a parallel fashion.