1198575-39-1

Basic information

• Product Name: 1,6-dimethyl-3,4-diphenyl-isoquinoline
• Synonyms: 1,6-dimethyl-3,4-diphenyl-isoquinoline
• CAS NO: 1198575-39-1
• Molecular Weight: 309.411
• Mol File: 1198575-39-1.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: 1,6-dimethyl-3,4-diphenyl-isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-dimethyl-3,4-diphenyl-isoquinoline(1198575-39-1)
• EPA Substance Registry System: 1,6-dimethyl-3,4-diphenyl-isoquinoline(1198575-39-1)

Safety Data

• Hazardous Substances Data: 1198575-39-1(Hazardous Substances Data)

Upstream product

• 64252-52-4 1-(1-diazoethyl)-4-methylbenzene 
• 501-65-5 diphenyl acetylene 
• 64252-53-5 4-methylacetophenone hydrazone 
• 1559065-82-5 N-chloro-1-(4-methylphenyl)ethanimine 
• 42070-98-4 1-(p-tolyl)ethylamine 
• 60672-33-5 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide 
• 21399-33-7 bis-(1-p-tolyl-ethylidene)-hydrazine 
• 96475-75-1 (E)‐ 1‐(p‐tolyl)ethan‐1‐one O‐acetyl oxime 
• 631-61-8 ammonium acetate 
• 122-00-9 para-methylacetophenone 
• 56587-84-9 (1E,2E)-1,2-bis(1-(p-tolyl)ethylidene)hydrazine 
• 1536277-77-6 C₁₁H₁₄N₂ 
• 5757-88-0 p-Methylacetophenone N,N-dimethylhydrazone 
• 89108-49-6 1-(1-azidovinyl)-4-methyl benzene 

Downstream Products

• 1383708-66-4 (E)-6-methyl-3,4-diphenyl-1-styrylisoquinoline 

Relevant articles and documents

Cobalt(III)-Catalyzed C-H/N-O Functionalizations: Isohypsic Access to Isoquinolines

C-H/N-O functionalizations by cobalt(III) catalysis allowed the expedient synthesis of a broad range of isoquinolines. Thus, internal and challenging terminal alkynes proved to be viable substrates for an isohypsic annulation, which was shown to proceed by a facile C-H cobaltation.

Ruthenium-Catalyzed Annulation of N -Cbz Hydrazones via C-H/N-N Bond Activation for the Rapid Synthesis of Isoquinolines

In this work, N -Cbz hydrazone has been employed as a rarely explored directing group for the synthesis of isoquinolines by annulation with internal alkynes via C-H/N-N activation using Ru catalyst. Additive as well as external oxidant-free rapid protocol

Rhodium-Catalyzed One-Pot Access to N-Polycyclic Aromatic Hydrocarbons from Aryl Ketones through Triple C-H Bond Activations

A Rh-catalyzed pot and step economic synthesis of aza-polycyclic aromatic hydrocarbons (N-PAHs) from readily available aryl ketones and alkynes has been disclosed. Additionally, a novel synthetic application of the well-known aminating reagent hydroxylamine-O-sulfonic acid (HOSA) has been explored as an in situ redox-neutral directing group for the formation of N-PAHs via isoquinoline. Multiple bond formation in a single operation through a cascade of triple C-H bond activations is the beauty of this protocol. The challenging annulations of two different alkynes in a regioselective fashion have been demonstrated effectively. Mechanistic studies reveal that 3,4-diphenyl-1-methylisoquinoline is an active intermediate for this one-pot transformation.

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.