57590-22-4Relevant academic research and scientific papers
A catalytic approach to the MH-031 lactone: Application to the synthesis of geralcin analogs
Tello-Aburto, Rodolfo,Lucero, Alyssa N.,Rogelj, Snezna
supporting information, p. 6266 - 6268 (2014/12/11)
A concise, 5-step synthesis of the hepatoprotective lactone MH-031 was achieved. Our approach utilizes several catalytic processes, namely, a Rauhut-Currier reaction, a chemoselective Fisher esterification, and a ring closing metathesis. Further elaboration of this lactone yielded the hydrazide natural product geralcin A and dihydrogeralcin B, a saturated analog of geralcin B. Biological evaluation of the latter indicated that the presence of the enehydrazide moiety in geralcin B is critical for anticancer activity.
