758-17-8

Basic information

• Product Name: N-methyl-N-formylhydrazine
• Synonyms: N-methyl-N-formylhydrazine;N-METHYL-N-FORMYLHYDRAZIDE;1-Methylformhydrazid;1-Formyl-1-methylhydrazine;1-Methyl-1-formylhydrazine;MFH;N-Methylformhydrazide;1-Methyl-1-formylhydrazid
• CAS NO: 758-17-8
• Molecular Formula: C₂H₆N₂O
• Molecular Weight: 74.10
• Mol File: 758-17-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 219-222 °C(Solv: ethanol (64-17-5))
• Boiling Point: 131.34°C (rough estimate)
• Flash Point: 25.5°C
• Appearance: /
• Density: 1.0968 (rough estimate)
• Vapor Pressure: 16.6mmHg at 25°C
• Refractive Index: 1.4368 (estimate)
• PKA: 3.12±0.10(Predicted)
• CAS DataBase Reference: N-methyl-N-formylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-formylhydrazine(758-17-8)
• EPA Substance Registry System: N-methyl-N-formylhydrazine(758-17-8)

Safety Data

• Hazardous Substances Data: 758-17-8(Hazardous Substances Data)

Usage

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Poison by ingestion route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also HYDRAZINE.

InChI:InChI=1/C2H6N2O/c1-4(3)2-5/h2H,3H2,1H3

Upstream product

• 107-31-3 Methyl formate 
• 302-15-8 methylhydrazine sulfuric acid 
• 60-34-4 methylhydrazine 
• 109-94-4 formic acid ethyl ester 
• 16694-46-5 ethyl formimidate hydrochloride 
• 64-18-6 formic acid 

Downstream Products

• 16568-02-8 Gyromitrin 
• 141573-95-7 ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 176969-34-9 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 
• 158585-86-5 ethyl 6,8-difluoro-1,4-dihydro-1-(N-methylformamido)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylate 
• 102618-08-6 2-(2,4-Dichlor-5-fluor-benzoyl)-3-(2-formyl-2-methylhydrazino)acrylsaeure-ethylester 

Relevant articles and documents

TYROSINE KINASE 2 INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF

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CRYSTALLINE FORM OF 6-(CYCLOPROPANECARBOXAMIDO)-4-((2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)AMINO)-N-(METHYL-D3) PYRIDAZINE-3-CARBOXAMIDE

Disclosed is crystalline Form B of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl) amino)-N-(methyl-d3)pyridazine-3-carboxamide. Form B is the HCl salt of a neat crystalline form. Characterization data for Form B are disclosed.

Synthesis and characterization of two formyl 2-tetrazenes

The synthesis of two formyl 2-tetrazenes, namely, (E)-1-formyl-1,4,4- trimethyl-2-tetrazene (2) and (E)-1,4-diformyl-1,4-dimethyl-2-tetrazene (3), by oxidation of (E)-1,1,4,4-tetramethyl-2-tetrazene (1) using potassium permanganate in acetone solution is presented. Compound 3 was also synthesized in an improved yield from the oxidation of 1-formyl-1-methylhydrazine (4 a) using potassium permanganate in acetone. Both compounds 2 and 3 were characterized by analytical (elemental analysis, GC-MS) and spectroscopic methods (1H, 13C, and 15N NMR spectroscopy, and IR and Raman spectroscopy). In addition, the solid-state structures of the compounds were confirmed by low-temperature X-ray analysis. (Compound 2: triclinic; space group P-1; a=5.997(1) A, b=8.714(1) A, c=13.830(2) A; α=107.35(1)°, β=90.53(1)°, γ=103.33(1)°; VUC=668.9(2) A3; Z=4; ρcalc=1.292 cm-3. Compound 3: monoclinic; space group P21/c; a=5.840(2) A, b=7.414(3) A, c=8.061(2) A; β=100.75(3) °; VUC=342(2) A3; Z=2; ρcalc=1. 396 g cm-3.) The vibrational frequencies of compounds 2 and 3 were calculated using the B3LYP method with a 6-311+G(d,p) basis set. We also computed the natural bond orbital (NBO) charges using the rMP2/aug-cc-pVDZ method and the heats of formation were determined on the basis of their electronic energies. Furthermore, the thermal stabilities of these compounds, as well as their sensitivity towards classical stimuli, were also assessed by differential scanning calorimetry and standard BAM tests, respectively. Lastly, the attempted synthesis of (E)-1,2,3,4-tetraformyl-2-tetrazene (6) is also discussed.