57619-22-4Relevant academic research and scientific papers
Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine
Henkel,Portoghese,Miller,Lewis
, p. 6 - 10,7, 9 (1976)
Crystalline perchlorate salts of aziridinium ions derived from phenoxybenzamine and dibenamine were prepared. Both aziridinium ions were tested on the rat vas deferens and found to possess α adrenergic potencies which were nearly identical with those of the parent compounds. The hydrolysis rates of phenoxybenzamine and dibenamine aziridinium ions in physiological medium were found to be 6.04 x 10-4 and 8.35 x 10-4 sec-1, respectively. The rates of cyclization of the parent amines in aqueous medium were 1.9 x 10-2 and 7.2 x 10-3 sec-1, respectively. The potencies and kinetic profiles indicate that the aziridinium ion is the only active species in α adrenergic blockade. Moreover, differences in potency between phenoxybenzamine and dibenamine appear to be exclusively to a difference in receptor affinity rather than to a difference in intrinsic alkylating ability.
Mild and efficient capture and functionalisation of CO2 using silver(i) oxide and application to 13C-labelled dialkyl carbonates
Tunbridge, Gemma A.,Baruchello, Riccardo,Caggiano, Lorenzo
, p. 4613 - 4621 (2013/05/08)
A high yielding three-component reaction between β-iodo ethylamine derivatives, MeOH and gaseous CO2 at ambient temperatures and pressures is reported using silver(i) oxide. Unfunctionalised alkyl iodides were also found to be effective in this transformation and their optimisation is also described. To highlight the ease and control with which gaseous CO 2 can be captured and functionalised under mild conditions, the reaction was performed using 13C-enriched CO2 to afford specifically 13C-carbonyl-labelled dialkyl carbonates with exquisite control of the isotopic purity in good yields and without the need for specialised equipment.
