57663-06-6Relevant academic research and scientific papers
Structure guided lead generation for M. Tuberculosis thymidylate kinase (Mtb TMK): Discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors
Naik, Maruti,Raichurkar, Anandkumar,Bandodkar, Balachandra S.,Varun, Begur V.,Bhat, Shantika,Kalkhambkar, Rajesh,Murugan, Kannan,Menon, Rani,Bhat, Jyothi,Paul, Beena,Iyer, Harini,Hussein, Syeed,Tucker, Julie A.,Vogtherr, Martin,Embrey, Kevin J.,McMiken, Helen,Prasad, Swati,Gill, Adrian,Ugarkar, Bheemarao G.,Venkatraman, Janani,Read, Jon,Panda, Manoranjan
, p. 753 - 766 (2015/01/30)
M. tuberculosis thymidylate kinase (Mtb TMK) has been shown in vitro to be an essential enzyme in DNA synthesis. In order to identify novel leads for Mtb TMK, we performed a high throughput biochemical screen and an NMR based fragment screen through which
Theoretical interpretations of electronic and fluorescence spectra of new 2(1H)-pyridone derivatives in solution and solid state
Shigemitsu, Yasuhiro,Hagimori, Masayori,Mizuyama, Naoko,Wang, Bo-Cheng,Tominaga, Yoshinori
, p. 940 - 949 (2013/09/23)
A combined experimental and computational study was performed for the spectroscopic properties of novel 2(1H)-pyridones. The compounds were found to be virtually non-fluorescence in solution while modestly fluorescent in solid state. The solvent effects o
Synthesis and reactivity of 3-amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones: development of a novel kinase-focussed library
Smyth, Lynette A.,Matthews, Thomas P.,Horton, Peter N.,Hursthouse, Michael B.,Collins, Ian
experimental part, p. 2843 - 2854 (2010/06/14)
3-Amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones represent a potentially attractive heteroaromatic scaffold for drug-discovery chemistry. In particular, the arrangement of hydrogen bond donor and acceptor groups in the bicyclic core can fulfil the requirement
Regioselective syntheses of functionalized 2-aminopyridines and 2-pyridinones through nucleophile-induced ring transformation reactions
Goel, Atul,Singh, Fateh V.,Sharon, Ashoke,Maulik, Prakas R.
, p. 623 - 626 (2007/10/03)
An efficient one-pot synthesis of 2-amino-6-aryl-4-methylsulfanylpyridines and 6-aryl-3-cyano-4-methylsulfanyl-2(1H)-pyridinone has been illustrated through ring transformation of 6-aryl-3-cyano-4-methylsulfanyl-2H-pyran-2-ones by urea through different r
Synthesis of 4-Methylthio-2(1H)-pyridone Derivatives Using Ketene Dithioacetals
Tominaga, Yoshinori,Kawabe, Masanori,Hosomi, Akira
, p. 1325 - 1331 (2007/10/02)
Reaction of various active methylene compounds with ketene dithioacetals, bis(methylthio)methylenemalononitrile (1a) and bis(methylthio)methylenecyanoacetamide (1b) gave the corresponding 3-cyano-4-methylthio-2(1H)-pyridone derivatives.The transformation
