577-62-8

Usage

Uses

Used in Flavor and Fragrance Industry:
ETHYL 2-(TRIFLUOROMETHYL)BENZOATE is used as a flavoring and fragrance agent for its pleasant aroma, enhancing the sensory experience of consumer products such as perfumes, cosmetics, and food products.
Used in Pharmaceutical Synthesis:
ETHYL 2-(TRIFLUOROMETHYL)BENZOATE is used as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new medications.
Used in Agrochemical Synthesis:
ETHYL 2-(TRIFLUOROMETHYL)BENZOATE is also utilized in the synthesis of agrochemicals, playing a role in the production of various agricultural products and chemicals.

InChI:InChI=1/C10H9F3O2/c1-2-15-9(14)7-5-3-4-6-8(7)10(11,12)13/h3-6H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 312-94-7 2-trifluoromethylbenzoyl chloride 
• 75-46-7 trifluoromethan 
• 1829-28-3 ethyl 2-iodobenzoate 
• 2314-97-8 iodotrifluoromethane 
• 7440-66-6 zinc 
• 447-60-9 2-(trifluoromethyl)benzonitrile 
• 100-47-0 benzonitrile 
• 93-89-0 benzoic acid ethyl ester 
• 76-05-1 trifluoroacetic acid 
• 444-30-4 2-(trifluoromethyl)phenol 
• 201230-82-2 carbon monoxide 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 344-95-6 2-(trifluoromethyl)benzohydrazide 

Relevant academic research and scientific papers

Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.

Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement

The application of a carbon-silicon bioisosteric replacement strategy to find new acaricides with improved properties led to the discovery of Sila-Cyflumetofen 6B, a novel and highly potent acaricide. The essential t-butyl group in the beta-ketonitrile ac

Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g–6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L? 1.

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety

A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L-1 and >80% activity at 250 mg L-1 against the two pests. Compounds E18 and E27 showed LC50 values of 38.5 and 30.8 mg L-1 against Mythimna separata, respectively, which were close to that of avermectin (29.6 mg L-1); compounds E5, E6, E9, E10, E15, E25, E26, and E27 showed 100% activity at 250 mg L-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity.

SO2F2-Mediated One-Pot Synthesis of Aryl Carboxylic Acids and Esters from Phenols through a Pd-Catalyzed Insertion of Carbon Monoxide

A one-pot Pd-catalyzed carbonylation of phenols into their corresponding aryl carboxylic acids and esters through the insertion of carbon monoxide has been developed. This procedure offers a direct synthesis of aryl carboxylic acids and esters from inexpensive and abundant starting materials (phenols, SO2F2 and CO) under mild conditions. This method tolerates a broad range of functional groups and is also applicable for the modification of complicated natural products.

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

A pharmaceutical intermediate trifluoromethyl substituted arene the synthetic method of the compound of

The invention relates to a method for synthesizing a medical intermediate trifluoromethyl substituted aromatic compound shown in a formula (I). The structural formula is as shown in the specification. The method comprises the following steps: adding a formula shown in a formula (II), a formula shown in a formula (III), a catalyst and alkali into an organic solvent at room temperature in a shading mode, heating to the temperature of 30-40 DEG C, and stirring for 20-30 minutes; adding an accelerant, heating to the temperature of 70-80 DEG C, carrying out heat preservation reaction and stirring reaction for 3-5 hours, thereby obtaining the compound shown in the formula (I), wherein the structural formula is as shown in the specification, and R refers to C1-C6 alkyl, cyano, halogens or ester groups. According to the trifluoromethylation method of the aromatic compound, the specific reaction substrate, catalyst, alkali, accelerant and organic solvent are adopted in the method, and good area location property is obtained by virtue of mutual coordination of the factors, so that the trifluoromethyl is introduced into a specific position (ortho-position of the substituted aromatic compound) at high yield, high yield is achieved, and the method has good research value and application potential.

METHOD FOR PRODUCING 2-TRIFLUOROMETHYL BENZOIC ACID ESTER

PROBLEM TO BE SOLVED: To provide a method for obtaining a 2-trifluoromethyl benzoic acid ester by a simple, efficient, and industrially excellent method using a starting substrate and a reagent which are inexpensive and industrially available without passing through an expensive synthetic intermediate. SOLUTION: The method for producing 2-trifluoromethyl benzoic acid ester represented by the following formula where n is an integer of 1-4 comprises: converting 2-halogen-substituted benzotrifluoride to a Grignard reagent; reacting the Grignard reagent with dialkyl carbonate; and subsequently subjecting to hydrolysis treatment. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Trifluorolactic demethylating agent powder, its manufacturing method using the same and method of manufacturing a trifluoromethyl group-containing compound

PROBLEM TO BE SOLVED: To provide a trifluoromethylation agent powder stable at room temperature and useful as a reaction reagent and a production method thereof, and a production method of trifluoromethyl group-containing compound.SOLUTION: A zinc powder is reacted with a trifluoromethyl iodide in a N,N-dimethylformamide solvent, and it is filtrated and concentrated to obtain a trifluoromethylation agent powder represented by general formula (1) that is (CF)ZnI (DMPU)(1), where DMPU represents N,N-dimethyl propylene urea and n represents an integer of 1 to 4, then it is reacted with substituted aromatic iodide in a presence of copper (I) catalyst to obtain a trifluoromethyl group-containing compound.

Synthesis, characterization and keto-enol tautomerism of novel 2-(trifluoromethyl)benzohydrazide derivatives

A series of novel 2-(trifluoromethyl)benzohydrazide derivatives were synthesized starting from 2,2,2-trifluoromethyl benzoic acid in three consecutive steps by using hydrazine hydride and aldehydes at room temperature. In above methodology a total of 21 n