57742-89-9Relevant academic research and scientific papers
Ir-catalyzed chemoselective reduction of β-amido esters: A versatile approach to β-enamino esters
Yang, Zhi-Ping,Lu, Guang-Sheng,Ye, Jian-Liang,Huang, Pei-Qiang
, p. 1624 - 1631 (2019)
The conversion of β-amido esters to β-enamino esters is an indispensable step for some synthetic approaches to alkaloids and related medicines. Known methods for such transformation are not only stepwise, but also proceed with low atom-efficiency. Herein, we report a direct and versatile approach that features the Ir-catalyzed chemoselective reduction of β-amido esters with 1,1,3,3-tetramethyldisiloxane (TMDS). In addition, a lack of some signals was observed in the 13C NMR spectra of some alicyclic β-enamino esters. This revealed a longstanding existing but being ignored phenomenon in the literature.
Br?nsted Acid Catalyzed Cyclization of Aminodiazoesters with Aldehydes to 3a'Carboxylatea'Na'Heterocycles
Jiao, Yang,Chen, Anrong,Yu, Bangkui,Huang, Hanmin
supporting information, p. 6031 - 6034 (2020/09/01)
A Br?nsted acid catalyzed cyclization of aminodiazoesters with aldehydes is described. This reaction features broad substrate generality and functional group compatibility, affording a wide range of 5a'7-membered 3-carboxylate-N-heterocycles containing different functional groups. The title products are able to be further elaborated through simple functional group transformations to produce synthetically useful N-heterocycles.
C(sp3)-H dehydrogenation and C(sp2)-H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles
He, Yan,Wang, Fang,Zhang, Xinying,Fan, Xuesen
, p. 4002 - 4005 (2017/04/11)
A novel and efficient synthesis of tetrahydropyridine (THP)-, dihydropyrrole (DHP)-, or tetrahydroazepine (THA)-3-carboxylates via cascade reactions of inactivated cyclic amines with CO and alcohols is presented. To our knowledge, this should be the first
Synthetic method of cyclic enamine-3-formic acid ester compound
-
Paragraph 0009; 0010, (2017/08/10)
The invention discloses a synthetic method of a cyclic enamine-3-formic acid ester compound and belongs to the field of organic synthesis technology. The main point of the technical scheme is as shown in the specification. In comparison with the prior art, the invention has the following advantages: (1) by the adoption of one-pot cascade reaction, tedious intermediate separation purification process is avoided, waste emission is decreased, and environmental burden is reduced; (2) raw materials are easily available; (3) the reaction is carried out at the temperature of minus 100 DEG C, condition is mild, and operation is simple; (4) the application range of a substrate is wide; and (5) atom economy of the reaction is high.
Photocycloaddition of Cyanoethylenes onto 1,4-Dihydro- and 1,4,5,6-Tetrahydropyridines
Donati, Donato,Fusi, Stefania,Ponticelli, Fabio
, p. 321 - 335 (2007/10/03)
Photochemical cycloaddition of cyanoethylenes onto the enamine system of the above titled compounds shows a different degree of selectivity depending on the position of the chiral centre present on the starting material, with a maximum effect for the 4-position.Steric configuration of both (Z)- and (E)-alkenes is retained during the photoaddition, strongly suggesting a concerted pathway to the cyclobutane photoadducts.
