57777-77-2

Upstream product

• 78272-50-1 p-chlorophenyl-β-cyanoethylphosphoric acid cyclohexylammonium salt 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 109-78-4 3-Hydroxypropionitrile 
• 57777-76-1 O^5'-(4-methoxy-trityl)-[3']thymidylic acid mono-(2-chloro-phenyl) ester 
• 62420-41-1 Phosphorochloridic acid 4-chloro-phenyl ester (2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 772-79-2 4-chlorophenylphosphorodichloridate 
• 13388-88-0 4-chlorophenyl phosphate 
• 106-48-9 4-chloro-phenol 
• 32666-92-5 p-chlorophenyl phosphorodichloridite 
• 78272-46-5 p-chlorophenyl-bis-(β-cyanoethyl)-phosphite 
• 78272-47-6 p-chlorophenyl-bis-(β-cyanoethyl)-phosphate 

Downstream Products

• 113339-92-7 C₅₂H₄₇Cl₂N₄O₁₄P 
• 113339-94-9 C₅₂H₄₈ClN₄O₁₄P 
• 113339-96-1 C₄₆H₄₅N₄O₁₄P 

Relevant academic research and scientific papers

NOUVELLE SYNTHESE SIMPLE DE DEOXYRIBONUCLEOSIDE-3'-ARYL-β-CYANOETHYL-PHOSPHATES

The deoxyribonucleoside-3'-aryl-β-cyanoethyl-phosphates, very used in the synthesis of oligodeoxynucleotides, were synthesized in high yields in a single step from the nucleoside derivatives with a monofunctional phosphorylating agent : cyclohexylammonium

A SIMPLIFIED STRATEGY FOR THE SYNTHESIS OF DIDEOXYRIBONUCLEOTIDE BLOCKS

The rapid synthesis of dideoxyribonucleotide blocks in 60-85percent isolated yields has been achieved by combining the phosphorylation and condensation steps in a sequential reaction series which also allows the recovery of unreacted nucleotides.