577978-62-2

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 4-(methoxymethoxy)-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4S)-
• CAS NO: 577978-62-2
• Molecular Formula: C26H35NO6
• Molecular Weight: 457.567
• Mol File: 577978-62-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 4-(methoxymethoxy)-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 4-(methoxymethoxy)-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4S)-(577978-62-2)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 4-(methoxymethoxy)-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4S)-(577978-62-2)

Safety Data

• Hazardous Substances Data: 577978-62-2(Hazardous Substances Data)

Upstream product

• 577978-34-8 3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-1-aza-5,7-disila-cyclopentacyclooctane-1-carboxylic acid tert-butyl ester 
• 577978-61-1 N-tert-butoxycarbonyl-1,4-dideoxy-1,4-imino-D-ribitol 
• 153172-31-7 (3aR,4R,6aS)-4-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole 
• 105990-41-8 (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-39-0 benzyl bromide 

Downstream Products

• 577978-35-9 3,5-di-O-benzyl-1,4-dideoxy-1,4-imino-N-(2,2,2-trichloroethoxycarbonyl)-D-ribitol 
• 872534-49-1 (2R,3R)-2,2,2-trichloroethyl-3-(benzyloxy)-2-(benzyloxymethyl)-4-oxopyrrolidine-1-carboxylate¹ 

Relevant articles and documents

Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase

The aza-C-nucleosides, Immucillin-H and Immucillin-G, are transition state analogue inhibitors of purine nucleoside phosphorylase, a therapeutic target for the control of T-cell proliferation. Immucillin analogues modified at the 2′-, 3′-, or 5′-positions of the azasugar moiety or at the 6-, 7-, or 8-positions of the deazapurine, as well as methylene -bridged analogues, have been synthesized and tested for their inhibition of human purine nucleoside phosphorylase. All analogues were poorer inhibitors, which reflects the superior capture of transition state features in the parent immucillins.