577991-17-4

Upstream product

• 577991-16-3 (1S,2R,4R,5R)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-4-iodobicyclo[3.1.0]hex-2-yl benzoate 
• 98-88-4 benzoyl chloride 
• 577991-15-2 (1S,2R,4S,5R)-4-[(phenylmethoxy)-5-(phenylmethoxy)methyl]bicyclo[3.1.0]hex-2-yl benzoate 
• 259659-49-9 (1S,2R,4S,5R)-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexan-2-ol 

Downstream Products

• 577991-19-6 (1'S,2'S,5'R)-1-{5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-yl}-5-methyl-3-(phenylcarbonyl)-1,3-dihydropyrimidine-2,4-dione 
• 577991-20-9 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-bicyclo[3.1.0]hex-3-en-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 577991-18-5 (1S,2R,5R)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-ol 

Relevant academic research and scientific papers

A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude

The synthesis and biological evaluation of a bicyclo[3.1.0]hexene nucleoside designed as a conformational mimic of the anti-HIV agent stavudine (1, D4T) is described. The unsaturated methanocarbocyclic pseudosugar of N-MCD4T (2) was constructed from an io

Recent advances in the synthesis of conformationally locked nucleosides and their success in probing the critical question of conformational preferences by their biological targets

The present work describes some recent approaches to the syntheses of three classes of locked-North nucleosides: β-D-ribo-, β-D-deoxyribo-, and β-D-dideoxy-ribonucleosides. The method developed for the latter class permitted access to a novel bicyclo[3.1.