577991-20-9

Upstream product

• 4330-20-5 N-3-benzoylthymine 
• 105-53-3 diethyl malonate 
• 184838-77-5 (+)-(1R,5S)-ethyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate 
• 577991-15-2 (1S,2R,4S,5R)-4-[(phenylmethoxy)-5-(phenylmethoxy)methyl]bicyclo[3.1.0]hex-2-yl benzoate 
• 259659-49-9 (1S,2R,4S,5R)-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexan-2-ol 
• 577991-16-3 (1S,2R,4R,5R)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-4-iodobicyclo[3.1.0]hex-2-yl benzoate 
• 577991-17-4 (1S,2R,5R)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-yl benzoate 
• 577991-19-6 (1'S,2'S,5'R)-1-{5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-yl}-5-methyl-3-(phenylcarbonyl)-1,3-dihydropyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure d- and l-bicyclo[3.1.0]hexenyl carbanucleosides and their antiviral evaluation

Based upon the fact that l-nucleosides have been generally known to be less cytotoxic than d-counterparts, l-bicyclo[3.1.0]hexenyl carbanucleoside derivatives with a fixed north conformation were designed and synthesized by employing a novel synthetic str

Recent advances in the synthesis of conformationally locked nucleosides and their success in probing the critical question of conformational preferences by their biological targets

The present work describes some recent approaches to the syntheses of three classes of locked-North nucleosides: β-D-ribo-, β-D-deoxyribo-, and β-D-dideoxy-ribonucleosides. The method developed for the latter class permitted access to a novel bicyclo[3.1.

A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude

The synthesis and biological evaluation of a bicyclo[3.1.0]hexene nucleoside designed as a conformational mimic of the anti-HIV agent stavudine (1, D4T) is described. The unsaturated methanocarbocyclic pseudosugar of N-MCD4T (2) was constructed from an io