53890-83-8

Usage

Structure

Bicyclic organic compound, isoindole derivative

Appearance

White to light yellow crystalline solid with a slight odor

Solubility

Soluble in organic solvents such as acetone and chloroform

Uses

Commonly used in the synthesis of pharmaceuticals and agrochemicals, production of active pharmaceutical ingredients, and as a building block in the synthesis of various compounds in the chemical and pharmaceutical industries.

Upstream product

• 7073-71-4 o-Bromo-α,α-dimethylbenzyl chloride 
• 103-71-9 phenyl isocyanate 
• 141636-29-5 2-phenyl-3,3-dimethylisoindoline-1-thione 
• 913257-14-4 3-(iodomethyl)-3-methyl-2-phenylisoindolin-1-one 
• 7073-69-0 2-(2-bromophenyl)propanol 
• 618443-94-0 2-iodo-N-isopropyl-N-phenylbenzamide 
• 609-67-6 2-Iodobenzoyl chloride 
• 102-97-6 Benzyl-isopropyl-amin 
• 88-67-5 2-Iodobenzoic acid 
• 3158-74-5 2-cyclopropylbenzoic acid 
• 57807-28-0 1-bromo-2-cyclopropylbenzene 
• 7073-70-3 1-bromo-2-isopropenylbenzene 
• 913257-08-6 2-(1-methylethen-1-yl)-N-phenylbenzamide 
• 918867-73-9 2-cyclopropyl-N-phenylbenzamide 

Downstream Products

• 141636-29-5 2-phenyl-3,3-dimethylisoindoline-1-thione 

Relevant academic research and scientific papers

KOtBu-mediated synthesis of dimethylisoindolin-1-ones and dimethyl-5-phenylisoindolin-1-ones: Selective C-C coupling of an unreactive tertiary sp3 C-H bond

A new reaction for the synthesis of dimethylisoindolinones has been presented from 2-halo-N-isopropyl-N-alkylbenzamide substrates and KO tBu by the selective C-C coupling of an unreactive tertiary sp 3 C-H bond. The reaction manifest

Hydriodic acid-mediated cyclization of a-substituted secondary 2-ethenylbenzamides: Synthesis of 2-substituted 2,3-dihydro-3,3-dimethyl-1H- isoindol-1-ones and 3,3-disubstituted (E)-1-(arylimino)-1,3- dihydroisobenzofurans

A new and facile method for the preparation of 2-substituted 2,3-dihydro-3,3-dimethyl-1H-isoindol-1-ones 3 and 3,3-disubstituted (E)-1-(arylimino)-1,3-dihydroisobenzofurans 6 has been developed. Thus, treatment of N-alkyl(or aryl)-2-(1-methylethen-1-yl)be

Palladium-catalyzed oxidative activation of arylcyclopropanes

(Diagram presented) Palladium chloride-catalyzed intramolecular activation of electroneutral cyclopropane derivatives results in cleavage of the cyclopropane ring followed by formation of heterocyclic derivatives. Phenols, carboxylic acids, and amide groups were considered as substituents ortho to the cyclopropane ring in this catalytic activation chemistry. The regioselectivity observed in the case of amide-containing substrates was different from that of carboxylic acid-containing substrates, ruling out simple cyclopropane isomerization followed by a Wacker oxidation as the mechanistic pathway.

Synthesis of 3,3-disubstituted isoindolin-1-ones via iodoamination of α-substituted secondary 2-vinylbenzamides

A new and simple method for the preparation of 3,3-disubstituted isoindolin-1-ones from α-substituted 2-bromostyrenes is described. Construction of the isoindolin-1-one skeleton was accomplished by treating α-substituted secondary 2-vinylbenzamides, easil

Photoreactions of Isoindoline-1-thiones with Alkenes: Unusual Formation of Tricyclic Isoindolines

Photochemical cycloaddition reactions of cyclic thioamides and alkenes have been examined.Irradiation of 2-arylisoindoline-1-thiones 1 in the presence of alkenes 2 gave the unexpected tricyclic isoindolines 3-18.The formation of tricyclic isoindolines can