57864-70-7

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 
• 104-93-8 p-methylanizole 
• 105-13-5 4-Methoxybenzyl alcohol 
• 61666-75-9 2-(4-metoxyphenyl)benzo[d][1,3]dithiole 
• 24588-72-5 2-(4-methoxyphenyl)-1,3-dithiane 
• 77925-51-0 2-(N,N-diethylaminosulfonyl)nitrobenzene 
• 874-90-8 4-methoxybenzonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-09-4 4-methoxybenzoic acid 
• 104-01-8 4-Methoxyphenylacetic acid 

Relevant academic research and scientific papers

Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst

Herein, we report a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and anin situgenerated non-native secondary amine. The catalyst consists of ano-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Transition metal-catalyzed C–H functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides

Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves C–H functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonami

Metal-free sequential dual oxidative amination of C(sp3)–H bonds: A direct approach to benzothiadiazine 1,1-dioxide derivatives

An efficient and metal-free Di-tert-butyl peroxide (DTBP)-promoted dual oxidative amination annulation of 2-amino arylsulfonamide with methylarene has been developed. This protocol provides straightforward access to benzothiadiazine 1,1-dioxide derivatives without using prefunctionalized substrates in good to excellent yields with good functional group tolerance.

Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols

Ruthenium-catalysed hydrogen transfer has been successfully used for the conversion of alcohols into either 2,3-dihydroquinazolines or quinazolines. The choice of reaction conditions allows for the selective formation of either heterocycle and the methodology can also be applied to the sulfonamide analogue.

Facile synthesis of 2H-1,2,4-benzothiadiazine 1,1-dioxides promoted by Sml2

2H-1,2,4-Benzothiadiazine 1,1-dioxides are prepared in good yields via reductive cyclisation of N,N-diethyl-o-nitrobenzenesulfonamides with appropriate nitriles promoted by Sml2 under mild and neutral conditions.