578703-92-1Relevant articles and documents
Direct access to 1,4-disubstituted 1,2,3-triazoles through organocatalytic 1,3-dipolar cycloaddition reaction of α,β-unsaturated esters with azides
Li, Wenjun,Zhou, Xiao,Luan, Yepeng,Wang, Jian
, p. 88816 - 88820 (2015/11/09)
DBU-catalyzed organocatalytic 1,3-dipolar cycloaddition reactions of α,β-unsaturated esters with azides have been developed. This strategy generates 1,4-disubstituted 1,2,3-triazoles in high yields with high regioselectivities. It is demonstrated that some of these products can be transformed into important pharmaceutical agents.
Arylazide cycloaddition to methyl propiolate: DFT-based quantitative prediction of regioselectivity
Molteni, Giorgio,Ponti, Alessandro
, p. 2770 - 2774 (2007/10/03)
Several 1-(4-substituted)-phenyl-4- or 5-methoxycarbonyl-1,2,3-triazoles have been synthesized by 1,3-dipolar cycloaddition of the corresponding arylazides to methyl propiolate in carbon tetrachloride. The regioselectivity of these reactions cannot be rat