57928-96-8Relevant articles and documents
Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates
Kao, Shih-Chieh,Lin, Yi-Ching,Ryu, Ilhyong,Wu, Yen-Ku
supporting information, p. 3639 - 3644 (2019/07/10)
Described is a tetrabutylammonium fluoride-mediated hydroxyalkylation reaction of phenols with cyclic carbonates. This operationally simple method enables the synthesis of a variety of aryl β-hydroxyethyl ethers in good to excellent yields with a very small amount of catalyst loading (0.1–1 mol%). Of particular note is the efficient conversion of aromatic diols and phloroglucinol to the corresponding bis- and tris-hydroxyethylated products. To further showcase the versatility of this protocol, guaifenesin was prepared with a single step by the condensation of guaiacol and glycerol carbonate. We also developed a flow ethoxylation process permitting the continuous synthesis of multiflorol. (Figure presented.).
Photo/nickel synergistic catalysis method for monoarylation of diol
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Paragraph 0040-0043; 0076-0078, (2018/09/13)
The invention discloses a photo/nickel synergistic catalysis method for monoarylation of a diol. The method directly uses a brominated aromatic hydrocarbon and a diol as raw materials, wherein the brominated aromatic hydrocarbon and the diol are simple and easy to obtain, and adopts a BODIPY organic photosensitizer and an inexpensive nickel source to synergistically catalyze cross-coupling of thediol and the brominated aromatic hydrocarbon without an additionally-added ligand to realize selective monoarylation of a diol compound, and a mono/dual arylation ratio is up to 18:1. The method disclosed by the invention has good tolerance of functional groups and is suitable for a plurality of diol compounds with different structures, such as o-diol, 1,3-diol, 1,4-diol and monodisperse polyethylene glycol; more importantly, the photosensitizer used in the method has a low using amount, the reaction temperature is close to room temperature, and the method is green, economical and highly-efficient; and the advantages make the method have higher scale synthetic value and can serve social and economic development.
Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ inhibitors
Hu, Zhongping,Zhang, Shasha,Zhou, Weicheng,Ma, Xiang,Xiang, Guangya
supporting information, p. 1854 - 1858 (2017/04/04)
The emergence and spread of multidrug-resistant strains of the human pathological bacteria are generating a threat to public health worldwide. In the current study, a series of PC190723 derivatives was synthesized and investigated for their antimicrobial activity. The compounds exhibited good activity against several Gram-positive bacteria as determined by comparison of diameters of the zone of inhibition of test compounds and standard antibiotics. Compound 9 with a fluorine substitution on the phenyl ring showed the best antibacterial activity in the series against M. smegmatis with the zone ratio of 0.62, and against S. aureus with the zone ratio of 0.44. The results from this study indicate that based on the unique 3-methoxybenzamide pharmacophore, compound 9 may represent a promising lead candidate against Gram-positive bacteria that are worthy of further investigation
Novel gambogic acid class derivative and preparation method and application thereof
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Paragraph 0016; 0017; 0021; 0022, (2018/02/04)
The invention belongs to the technical field of antitumor drug preparation and discloses a novel gambogic acid class derivative and a preparation method and application thereof. The derivative of the structure mainly modifies gambogic acid C-30, and a plu
The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy)caffeine analogues
Strydom,Bergh,Petzer
, p. 513 - 518 (2013/01/15)
Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an IC 50 value of 0.383M towards MAO-B. In an attempt to improve on the inhibition potency of this compound and to discover highly potent reversible MAO-B inhibitors, in the present study, a series of 8-(2-phenoxyethoxy)caffeine analogues containing various substituents on C4 of the phenoxy ring, were synthesized and evaluated as inhibitors of human MAO-A and -B. The results show that the 8-(2-phenoxyethoxy)caffeine analogues are selective and reversible MAO-B inhibitors with the most potent homologue, 8-{2-[4-(trifluoromethyl) phenoxy]ethoxy}caffeine, exhibiting an IC50 value of 0.061μM. These highly potent inhibitors are useful leads in the design of therapies for neurodegenerative disorders such as Parkinsons disease. Georg Thieme Verlag KG Stuttgart New York.
A switchable ferrocene-based [1]rotaxane with an electrochemical signal output
Li, Hong,Zhang, Hui,Zhang, Qiong,Zhang, Qi-Wei,Qu, Da-Hui
supporting information, p. 5900 - 5903 (2013/02/23)
A [1]rotaxane, in which a linear rod is attached to one cyclopentadienyl (Cp) ring of a ferrocene unit and threaded into a dibenzo-24-crown-8 connected to the other Cp ring, was prepared. The mechanical motion of the rod-like part relative to the macrocycle has been demonstrated using 1H NMR spectroscopy. Cyclic voltammetry (CV) showed that the system can be chemically switched between electrochemically reversible and irreversible states, depending on the inclusion and exclusion of the ammonium/amine group from the macrocycle.
Redox behavior of ferrocene-containing rotaxane: Transposition of the rotaxane wheel by redox reaction of a ferrocene moiety tethered at the end of the axle
Kihara, Nobuhiro,Hashimoto, Makiko,Takata, Toshikazu
, p. 1693 - 1696 (2007/10/03)
Matrix presented. A rotaxane with a ferrocene moiety at the axle terminus was prepared. The redox potential of the ferrocene moiety decreased by ca. 80 mV when the rotaxane had a crown ether wheel capable of moving on the axle. Thus, the stabilization of
