57943-60-9

Upstream product

• 67-56-1 methanol 
• 767-00-0 4-cyanophenol 
• 75-36-5 acetyl chloride 

Downstream Products

• 106050-85-5 4-(5'-methyl-1H-benzimidazol-2'-yl)phenol hydrochloride 
• 106050-86-6 4-(5'-chloro-1H-benzimidazol-2'-yl)phenol hydrochloride 
• 106050-91-3 4-<5'-(4''-methylpiperazin-1''-yl)-1H-benzimidazol-2'-yl>phenol hydrochloride 
• 15535-98-5 p-hydroxybenzamidine 
• 38148-63-9 p-amidinophenol hydrochloride 
• 347165-36-0 ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)-1H-benzimidazole-5-carboxylate 
• 1448673-75-3 tert-butyl 2-[(4-{2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]ethoxy}phenyl)(imino)methyl]hydrazinecarboxylate 
• 1448673-76-4 tert-butyl 2-[{4-[2-(aminooxy)ethoxy]phenyl}(imino)methyl]hydrazinecarboxylate 
• 1448673-74-2 tert-butyl 2-[(4-hydroxyphenyl)(imino)methyl]hydrazinecarboxylate 

Relevant academic research and scientific papers

Synthesis and anti cervical cancer activity of novel 5H-thiochromeno [4,3-d]pyrimidines

A series of novel 5H-Thiochromeno[4,3-d]pyrimidine derivatives were synthesized, purified and characterized by different spectroscopy techniques such as1H NMR,13C NMR, Mass and Elemental Analysis. The new compounds were evaluated for their anti-cervical cancer activity on Human Cervical Cell Line HeLa. They were found to be potent anti-cervical cancer agents with GI50 values less than 10 μg/mL with respect to positive control drug Adriamycin.

VASCULAR ADHESION PROTEIN-1 (VAP-1) MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Synthesis and antibacterial activities of Yanglingmycin analogues

The synthesis of Yanglingmycin and its enantiomer, along with eighteen Yanglingmycin analogues is reported. The structures were confirmed mainly by analyses of NMR spectral data. Antibacterial activity assays showed that Yanglingmycin and some of its analogues exhibited significant antibacterial activities against two important agricultural pathogenic bacteria, Ralstonia solanacearum and Pseudomonas syringae pv. actinidiae, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 15.62 μg/mL. The antibacterial activities exhibited by Yanglingmycin and its analogues are promising, suggesting potential in the development of compounds for novel bactericides.

AMIDINE SUBSTITUTED BETA - LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS

The present invention relates to novel β-lactam compounds of formula (I), their preparation and use. In particular, this invention relates to novel β-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

A series of 1-cycloalkyl-2-phenyl-1H-benzimidazole-5-carboxylic acid derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase (RdRp). A SAR study was performed and led to identify the 2-[(4-diarylmeth

4-(Cyclic amidino)phenols-preparation and use in a diamidine synthesis

The Pinner synthesis was applied to the preparation of 4-(cyclic amidino)phenols in high yields from readily available 4-hydroxybenzimidic acid methyl ester hydrochloride and diaminoalkanes. An alternative attempt was made to convert 4-(hydroxy)thiobenzamide to 4-(1,4,5,6-terahydro-5- hydroxy-2-pyrimidinyl)phenol. A procedure for the preparation of 3,6-bis(4- hydroxyphenyl)-1,2,4,5-tetrazine is reported here. The syntheses of 2,4- bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyrimidine and 2-chloro-4-[4- (4,5-dihydro-1H-imidazol-2-yl)-phenoxy]pyrimidine exemplify the use of the title synthetic intermediates.