57978-41-3

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 2-[(3-chlorophenyl)amino]-
• CAS NO: 57978-41-3
• Molecular Formula: C12H9ClN2O2
• Molecular Weight: 248.669
• Mol File: 57978-41-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 2-[(3-chlorophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 2-[(3-chlorophenyl)amino]-(57978-41-3)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 2-[(3-chlorophenyl)amino]-(57978-41-3)

Safety Data

• Hazardous Substances Data: 57978-41-3(Hazardous Substances Data)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 110546-46-8 2-<(3-chlorophenyl)amino>-3-pyridinecarbonyl chloride 
• 51703-20-9 ethyl 2-(3-chloroanilino)nicotinate 
• 1482446-99-0 2-(3-chloroanilino)nicotinic acid hydrazide 
• 127555-61-7 1,3-dihydro-1-(3-chlorophenyl)-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one 
• 128271-37-4 (3-Chloro-phenyl)-(3-phenylsulfanylmethyl-pyridin-2-yl)-amine 

Relevant articles and documents

Synthesis, anti-inflammatory and analgesic activities of arylidene-2-(3-chloroanilino)nicotinic acid hydrazides

A new series of 2-(3-chloroanilino)nicotinic acid hydrazides 12a-p were synthesized and evaluated for their anti-inflammatory and analgesic activities. Most of the compounds have shown anti-inflammatory activity with a moderate-to-excellent activity range. Among them, 3-chloro 12d and 4-methoxyphenyl derivatives 12i exhibited the most potent anti-inflammatory activity relative to niflumic acid as the reference drug (95, 87, and 81 % reductions in inflammation, respectively). The compounds with the highest anti-inflammatory activity were subjected to analgesic assay and showed moderate-to-excellent analgesic activities. The 2,4-dimethoxyphenyl derivative (12j) exhibited the highest analgesic activity relative to niflumic acid (99.6 and 68 % activity, respectively).

Catalyst-free amination of 2-chloronicotinic acid in water under microwave irradiation

A simple, efficient and environmental friendly method for the synthesis of 2-arylaminonicotinic acids derivatives by reacting 2-chloronicotinic acid with anilines with potassium carbonate as the base and water as the media under microwave irradiation is described. The synthesis of 2-arylaminonicotinic acids is important because they are nonsteroidal anti-inflammatory drugs.

Activation and inhibition of kidney CLC-K chloride channels by fenamates

CLC-K Cl- channels are selectively expressed in kidney and ear, where they are pivotal for salt homeostasis, and loss-offunction mutations of CLC-Kb produce Bartter's syndrome type III. The only ligand known for CLC-K channels is a derivative o