57984-77-7

Upstream product

• 62-53-3 aniline 
• 13820-14-9 4-methylbenzonitrile oxide 
• 104-87-0 4-methyl-benzaldehyde 
• 36288-37-6 N-hydroxy-4-methylbenzenecarboximidoyl chloride 
• 106-49-0 p-toluidine 
• 3235-02-7 p-methylbenzaldehyde oxime 

Downstream Products

• 835-71-2 2-(4-methylphenyl)-1,3-benzoxazole 
• 120-03-6 2-(p-tolyl)-1H-benzimidazole 
• 1453261-06-7 C₇₄H₁₂N₂ 
• 4300-33-8 N-(4-methylphenyl)-N'-phenylurea 
• 19244-07-6 N-phenyl-N'-(4-methylphenyl)carbodiimide 
• 63105-02-2 3-phenyl-4-p-tolyl-3H-[1,2,3,5]oxathiadiazole 2-oxide 

Relevant academic research and scientific papers

Regioselective cleavage of O-benzyl-N-arylamidoximes: Synthesis of N-aryl amidines and amidoximes

O-Benzyl-N-arylamidoximes have been regioselectively deprotected to provide either N-aryl amidines or amidoximes. As a result, the targeted compounds can now be prepared using palladium-catalyzed N-arylation chemistry.

Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction

A molecular I2-promoted one-pot synthesis of 2-aryl benzoxazoles has been developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chemicals. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction, and provided a potential route for introducing certain groups at any site of the scaffold.

FeCl3·6H2O-mediated reaction of [60]fullerene with amidoximes

A FeCl3·6H2O-mediated reaction of [60]fullerene with amidoximes for the preparation of fulleroimidazolines has been presented. This reaction shows a wide substrate scope, and the products obtained from alkyl-substituted amidoximes ar

Practical synthesis of N -substituted cyanamides via tiemann rearrangement of amidoximes

A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.

Unexpected C-C bond cleavage: Synthesis of 1,2,4-oxadiazol-5-ones from amidoximes with pentafluorophenyl or trifluoromethyl anion acting as leaving group

An unexpected C-C bond cleavage has been observed on pentafluorobenzoylamidoximes under mild basic conditions. This observation has been exploited to develop a new synthesis of 1,2,4-oxadiazol-5-ones from amidoximes using pentafluorobenzoyl chloride or trifluoroacetic anhydride (TFAA) as a double acylating agent. The pentafluorophenyl anion and the trifluoromethyl anion acted as leaving groups in this transformation.