58059-47-5

Basic information

• Product Name: 3-AMINO-6-(4-CHLOROPHENYL)PYRIDAZINE
• Synonyms: 6-(4-Chloro-phenyl)-pyridazin-3-ylamine;3-AMINO-6-(4-CHLOROPHENYL)PYRIDAZINE;6-(4-chlorophenyl)pyridazin-3-amine
• CAS NO: 58059-47-5
• Molecular Formula: C₁₀H₈ClN₃
• Molecular Weight: 205.64
• Mol File: 58059-47-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 427.502 °C at 760 mmHg
• Flash Point: 212.346 °C
• Appearance: /
• Density: 1.323 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-AMINO-6-(4-CHLOROPHENYL)PYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-6-(4-CHLOROPHENYL)PYRIDAZINE(58059-47-5)
• EPA Substance Registry System: 3-AMINO-6-(4-CHLOROPHENYL)PYRIDAZINE(58059-47-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 58059-47-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8ClN3/c11-8-3-1-7(2-4-8)9-5-6-10(12)14-13-9/h1-6H,(H2,12,14)

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 58059-29-3 6-(p-chlorophenyl)-3-chloropyridazine 
• 2166-13-4 6-(p-chlorophenyl)-3(2H)-pyridazinone 
• 187973-60-0 6-iodopyridazine-3-amine 
• 60478-25-3 3-(4-chloro-phenyl)-6-hydrazino-pyridazine 

Downstream Products

• 1629613-11-1 7-(4-chlorophenyl)-4-(trifluoromethyl)-2H-pyrimido[1,2-b]pyridazin-2-one 
• 105538-41-8 2-(3-carbethoxypropyl)-3-imino-6-(p-chlorophenyl)-2,3-dihydropyridazine 
• 1421637-28-6 3-amino-4-bromo-6-(4-chlorophenyl)pyridazine 
• 1421637-40-2 N-allyl-3-(4-chlorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-39-9 N-propyl-3-(4-chlorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-38-8 N-cyclohexyl-3-(4-chlorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-37-7 N-butyl-3-(4-chlorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 143268-30-8 2-<(3-methoxy-5-isothiazolyl)methyl>-3-imino-6-(p-chlorophenyl)-2,3-dihydropyridazine hydrochloride 
• 105538-26-9 6-Amino-3-(4-chloro-phenyl)-1-(3-ethoxycarbonyl-propyl)-pyridazin-1-ium; bromide 
• 143268-27-3 2-<(3-methoxy-5-isoxazolyl)methyl>-3-imino-6-(p-chlorophenyl)-2,3-dihydropyridazine hydrochloride 

Relevant articles and documents

Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

Gabazine, a γ-aminobutyric acid type A (GABAA) receptor antagonist, has previously been reported to inhibit the binding of [3H]NCS-382, a representative ligand of the high-affinity binding site for the neuroactive substance γ-hydroxy

Mild and direct access to 7-substituted-4-trifluoromethylpyrimido[1,2- b ]pyridazin-2-one systems

New and efficient methods for the synthesis of 7-substituted-4- trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtained in good to excellent yields from 3-amino-6-chloropyridazine and ethyl 4,4,4-trifluorobut-2- ynoate. Georg Thieme Verlag Stuttgart · New York.

Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531)

Microwave-enhanced, highly efficient protocols for the synthesis of synthetically and biologically important 2,3,6-trisubstituted pyridazine architectures have been developed by sequential amination/Suzuki coupling/alkylation reactions. This powerful strategy is an economical and highly chemoselective protocol for the synthesis of diversified pyridazines. The total synthesis of gabazine (SR-95531) has been achieved using a versatile strategy in four steps and 73% overall yield.