58059-29-3

Basic information

• Product Name: 3-CHLORO-6-(4-CHLOROPHENYL)-PYRIDAZINE
• Synonyms: 3-CHLORO-6-(4-CHLOROPHENYL)-PYRIDAZINE;1-Chloro-4-(6-Chloropyridazin-3-yl)benzene, 3-Chloro-6-(4-chlorophenyl)-1,2-diazine
• CAS NO: 58059-29-3
• Molecular Formula: C₁₀H₆Cl₂N₂
• Molecular Weight: 225.07
• Mol File: 58059-29-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 200-201 °C(Solv: ethanol (64-17-5))
• Boiling Point: 400.939 °C at 760 mmHg
• Flash Point: 228.615 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• PKA: 0.14±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-6-(4-CHLOROPHENYL)-PYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-6-(4-CHLOROPHENYL)-PYRIDAZINE(58059-29-3)
• EPA Substance Registry System: 3-CHLORO-6-(4-CHLOROPHENYL)-PYRIDAZINE(58059-29-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 58059-29-3(Hazardous Substances Data)

Usage

General Description

3-Chloro-6-(4-chlorophenyl)-pyridazine is a chemical compound with the molecular formula C10H6Cl2N2. It is a pyridazine derivative with two chlorine atoms and a phenyl ring attached to the pyridazine ring. 3-CHLORO-6-(4-CHLOROPHENYL)-PYRIDAZINE is commonly used as a building block for the synthesis of various pharmaceuticals and agrochemicals. It can also be utilized in the development of specialty chemicals and materials. 3-Chloro-6-(4-chlorophenyl)-pyridazine is primarily used as an intermediate in organic synthesis and can be found in research laboratories and chemical manufacturing facilities.

InChI:InChI=1/C10H6Cl2N2/c11-8-3-1-7(2-4-8)9-5-6-10(12)14-13-9/h1-6H

Upstream product

• 99-91-2 para-chloroacetophenone 
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• 53-73-6 angiotensinamide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 89523-62-6 (4-chlorophenyl)zinc(II) chloride 
• 2166-13-4 6-(p-chlorophenyl)-3(2H)-pyridazinone 
• 108-90-7 chlorobenzene 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 1079-73-8 6-(4-chlorophenyl)-4,5-dihydro-3(2H)-pyridazinone 

Downstream Products

• 66548-70-7 6-(4-chloro-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine 
• 67972-20-7 N'-[6-(4-chloro-phenyl)-pyridazin-3-yl]-hydrazinecarboxylic acid ethyl ester 
• 66866-22-6 3-phenyl-6-(4'-chlorophenyl)-1,2,4-triazolo[4,3-b]pyridazine 
• 1268133-93-2 3-(4'-tolyl)-6-(4'-chlorophenyl)-1,2,4-triazolo[4,3-b]pyridazine 
• 1446021-18-6 3-(4-chlorophenyl)-6-iodopyridazine 
• 67820-99-9 N'-[6-(4-chloro-phenyl)-pyridazin-3-yl]-N'-(2-hydroxy-ethyl)-hydrazinecarboxylic acid ethyl ester 
• 1446019-91-5 C₂₄H₂₅ClN₄O 
• 690265-67-9 3-(4-chloro-phenyl)-6-trimethylsilanylethynyl-pyridazine 
• 66548-72-9 6-(4-chloro-phenyl)-3-ethyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 58059-47-5 3-amino-6-(p-chlorophenyl)pyridazine 
• 105538-26-9 6-Amino-3-(4-chloro-phenyl)-1-(3-ethoxycarbonyl-propyl)-pyridazin-1-ium; bromide 
• 93182-12-8 3-{4-[(butylcarbamoyl)oxy]piperidino}-6-(4-chlorophenyl)pyridazine 
• 93182-06-0 Methyl-carbamic acid 1-[6-(4-chloro-phenyl)-pyridazin-3-yl]-piperidin-4-yl ester 
• 60478-25-3 3-(4-chloro-phenyl)-6-hydrazino-pyridazine 

Relevant articles and documents

Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives

Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used reference standard, IC50 = 226 μM), that, they may represent promising hits for treatment of cardiovascular disorders. The observed activity was validated by a statistically significant QSAR model (N = 32, n = 6, R2 = 0.811782, R2cvOO = 0.7153, R2cvMO = 0.7209, F = 17.9708, s2 = 9.65226 × 10-8) that was obtained employing CODESSA-Pro software.

Synthesis, antituberculostatic, antifungal and antibacterial activities of 3-substituted phenyl-6-substituted phenyl-1,2,4-triazolo[4,3-b]pyridazines

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Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.