581098-40-0

Upstream product

• 581098-38-6 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydro-2H-imidazole-2-thione 
• 457081-00-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one 
• 302839-09-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 461-87-0 2-fluoro-4-methylpyridine 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 868993-81-1 4-[2-(ethylthio)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridin-2-ol 
• 868993-97-9 4-[4-(4-fluorophenyl)-2-(phenylthio)-1H-imidazol-5-yl]pyridin-2(1H)-one 

Relevant academic research and scientific papers

TETRACYCLIC INHIBITORS OF JANUS KINASES

The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of sub