58187-62-5Relevant academic research and scientific papers
Copper-catalyzed radical oxyallylation of olefins for the construction of alkene-containing isoxazolines
He, Xiaoxue,Qian, Lijie,Dai, Yuyu,Yan, Xinhuan,Li, Xiaoqing,Xu, Xiangsheng
supporting information, (2021/05/31)
A radical-mediated approach to alkene oxyallylation using allylic oximes is described. The reaction proceeds under copper-catalytic redox-neutral conditions and tolerates various functional groups. This protocol thus enables the synthesis of structurally valuable isoxazolines and the introduction of a versatile olefin motif in a single step.
Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem-Difluoroalkenes
Liu, Haidong,Ge, Liang,Wang, Ding-Xing,Chen, Nan,Feng, Chao
supporting information, p. 3918 - 3922 (2019/02/19)
A novel strategy for the expedient construction of CF3-embeded tertiary/quarternary carbon centers was developed by taking advantage of photoredox catalysis. Thanks to a key step of single-electron oxidation, electron-rich gem-difluoroalkenes, which otherwise are essentially reluctant towards F-nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation, as well as functionalization, of α-CF3-substituted benzylic radical intermediates using cheap and readily available starting materials.
Concise synthesis of ketoallyl sulfones through an iron-catalyzed sequential four-component assembly
Xiao, Fuhong,Liu, Chao,Wang, Dahan,Huang, Huawen,Deng, Guo-Jun
supporting information, p. 973 - 977 (2018/03/13)
A three starting material four component reaction (3SM-4CR) strategy is described to prepare β-acyl allylic sulfones from methyl ketones, sodium sulfinates and dimethylacetamide (DMA) in an iron-catalyzed oxidative system. In this process, DMA was used as a dual synthon to provide two carbons. A broad range of functional groups were tolerated in this reaction system.
1-phenyl-2-(phenylsulfonyl)methyl-2-propylene-1-one, derivative and synthesis methods thereof
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Paragraph 0090, (2018/06/28)
The invention mainly relates to a one-pot method for efficient and environment-friendly production of 1-phenyl-2-(phenylsulfonyl)methyl-2-propylene-1-one and a derivative from multiple components including N,N-dimethylacetamide as a carbon source to provide two synthons as well as ketone compounds and sodium sulfinate compounds under the joint action of a metal lewis acid catalyst, an oxidizing agent and a phase transferring catalyst which are cheap and easy to obtain.
Umpolung synthesis of branched α-functionalized amines from imines via photocatalytic three-component reductive coupling reactions
Fuentes De Arriba, Angel L.,Urbitsch, Felix,Dixon, Darren J.
supporting information, p. 14434 - 14437 (2016/12/23)
A three component reductive coupling reaction of a (hetero)aromatic amine, a (hetero)aromatic aldehyde and an electron deficient olefin catalysed by eosin Y under green LED light irradiation, for the direct generation of γ-amino acid derivatives, is described. This new umpolung synthesis of amines, which exploits the high nucleophilicity of a putative α-amino radical intermediate, generated via single electron reduction of the in situ generated imine from the Hantzsch ester terminal reductant, is efficient, operationally simple, broad in scope and offers a complementary strategy to existing synthetic approaches.
Stannylated allylsulfones as versatile new building blocks
Kazmaier, Uli,Wesquet, Alexander
, p. 1271 - 1274 (2007/10/03)
Propargylic sulfones undergo regioselective hydrostannation in the presence of Mo(CO)3(CNt-Bu)3(MoBl3), giving rise to stannylated allyl sulfones. These are interesting building blocks, because in the first step the vinyls
Palladium catalysed tetramolecular cascade processes incorporating allene and carbon monoxide
Grigg, Ronald,Brown, Stephen,Sridharan, Visuvanathar,Uttley, Michael D.
, p. 5031 - 5034 (2007/10/03)
Chemo- and regio-specific palladium catalysed four component cascade processes, involving formation of 4 new bonds, initiated by oxidative addition of Pd(0) with aryl/heteroaryl iodides followed by sequential incorporation of CO(latm), allene (latrn) and an S- or N-nucleophile[PhSO2- or (RNTs)-] occur in good to excellent yield at 50°C.
