58249-87-9Relevant academic research and scientific papers
Aziridine ring-containing chiral ligands as highly efficient catalysts in asymmetric synthesis
Rachwalski, Michal,Jarzynski, Szymon,Lesniak, Stanislaw
, p. 421 - 425 (2013/06/27)
Enantiomerically pure bidentate heteroorganic ligands built on an achiral skeleton containing hydroxyl and aziridine moieties as nucleophilic centers, capable of binding various organometallic reagents, have proven to be highly efficient catalysts in the enantioselective addition of diethylzinc and phenylethynylzinc to aryl and alkyl aldehydes to give the desired chiral products in high chemical yields (up to 90%) and with ees of up to 95%. The influence of the stereogenic center located in the carbon atom in the aziridine moiety on the stereochemical course of the reaction is reported.
Cyclisation reactions of 2-substituted benzoylphosphonates with trialkyl phosphites via nucleophilic attack on a carbonyl-containing ortho substituent
Cheong, Yuen-Ki,Duncanson, Philip,Griffiths, D. Vaughan
, p. 2329 - 2338 (2008/09/18)
Dimethyl 2-acetoxy- and dimethyl 2-benzoyloxy-benzoylphosphonate undergo cyclisation and deoxygenation in the presence of excess trimethyl phosphite to give dimethyl (3-methyl-1-benzofuran-2-yl)phosphonate and dimethyl (3-phenyl-1-benzofuran-2-yl)phosphonate, respectively. The reaction pathway has been shown to involve phosphite attack on initially formed tricyclic dioxaphospholane intermediates with the subsequent loss of two molecules of trimethyl phosphate. In the absence of additional trimethyl phosphite the initially formed tricyclic dioxaphospholane intermediates lose one molecule of trimethyl phosphate and then undergo a novel rearrangement to give β-ketophosphonates. The mechanism for this reaction helps explain some previously reported epoxide rearrangements. In contrast, the initially formed anionic intermediate from the reaction of dimethyl 2-benzoyloxymethylbenzoylphosphonate with trimethyl phosphite undergoes decomposition to give a carbene intermediate which is trapped by the trimethyl phosphite to give an ylidic phosphonate.
SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION
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Page/Page column 25, (2008/06/13)
The invention relates to substituted cyclohexyl-1,4-diamine derivatives, to a method for their production, to medicaments containing said compounds and to the use of substituted cyclohexyl-1,4-diamine derivatives for producing medicaments.
Use of nitrogen heterocyclic aromatic derivatives in the topical treatment of the epithelial tissues diseases
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, (2008/06/13)
Derivatives of general chemical formula L(I) and (IV) are used in the topical treatment of diseases of the epithelial tissues, like psoriasis (epidermis) and ulcerative colitis L(lower intestine). These compounds display a high efficacy when administered for example by epicuaneous route in the case of dermatological illnesses like psoriasis, atopic dermatitis and other similar affections, or when administered by oral or rectal route in the case of diseases of the epithelia of the lower intestine like the ulcerative colitis and Crohn's disease.
3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and uses
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, (2008/06/13)
3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula STR1 wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R5 CO-- wherein R5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R1, R2 and R3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R2 and R3 together may represent a methylenedioxy group, and R4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R5 CO-- group wherein R5 contains 4 or less carbon atoms, R4 must contain 5 or more carbons. These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.
