58305-26-3Relevant articles and documents
'AND'-based fluorescence scaffold for the detection of ROS/RNS and a second analyte
Odyniec, Maria L.,Sedgwick, Adam C.,Swan, Alexander H.,Weber, Maria,Tang, T. M. Simon,Gardiner, Jordan E.,Zhang, Miao,Jiang, Yun-Bao,Kociok-Kohn, Gabriele,Elmes, Robert B. P.,Bull, Steven D.,He, Xiao-Peng,James, Tony D.
, p. 8466 - 8469 (2018/08/04)
Traditionally, fluorescence probes have focused on the detection of a single biomarker for a specific process. In this work, we set out to develop a number of fluorescence probes that enable the detection of a chosen analyte in the presence of reactive oxygen/nitrogen species (ROS/RNS). These fluorescence probes when activated result in the formation of the highly fluorescent pink dye, resorufin. Therefore, we have labelled these fluorescent probes as -Pinkments'. Our first -Pinkment' was shown to detect biologically relevant concentrations of ONOO- and have an excellent selectivity against other ROS/RNS. Pinkment-OH was developed to provide a core unit which could be easily functionalised to produce a range of -AND' based fluorescence probes for the detection of ROS/RNS and a second analyte. For proof of concept, we synthesised Pinkment-OTBS and Pinkment-OAc. These -AND'-based probes were successfully shown to detect ROS/RNS and F- or esterase, respectively.
Asymmetric phase-transfer catalyzed glycolate alkylation, investigation of the scope, and application to the synthesis of (-)-ragaglitazar
Andrus, Merritt B.,Hicken, Erik J.,Stephens, Jeffrey C.,Karl Bedke
, p. 9470 - 9479 (2007/10/03)
Asymmetric glycolate alkylation using a protected acetophenone surrogate under solid-liquid phase-transfer conditions is a new approach to the synthesis of 2-hydroxy esters and acids. Diphenylmethyloxy-2,5-dimethoxyacetophenone 1 with a trifluorobenzyl ci
