58342-57-7Relevant academic research and scientific papers
NEUROLOGICALLY-ACTIVE COMPOUNDS
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Page/Page column 11; 16, (2008/06/13)
The invention provides a compound of the formula (I): wherein R is methyl, ethyl, propyl, isopropyl, butyl, pentyl, neo-pentyl or cyclohexyl, or a salt or solvate thereof. These compounds are selective GABAC receptor antagonists. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof. The invention also provides methods of enhancing the cognitive activity of an animal and methods of stimulating memory capacity in an animal, comprising the step of administering to the animal an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof.
An Efficient Synthesis of 4(S)-Hydroxycyclopent-2-enone
Khanapure, Subhash P.,Najafi, Nahid,Manna, Sukumar,Yang, Jing-Jing,Rokach, Joshua
, p. 7548 - 7551 (2007/10/03)
An efficient synthesis of 4(S)-hydroxycyclopent-2-enone of high optical purity, a key synthon used in natural product synthesis, is described.The method is suitable for large-scale synthesis.
Novel Copper Complexes of Chiral Diphosphines: Preparation, Structure, and Use To Form Rhodium Complex Catalysts for Chiral Hydrogenations
Townsend, John M.,Blount, John F.,Sun, Ruen Chu,Zawoiski, Sonja,Valentine, Donald
, p. 2995 - 2999 (2007/10/02)
Treatment of chiral diphosphines 5a-c and 13 ("DIOP", aryl derivatives and related substances) with CuCl in boiling ethanol gave complexes having the composition n, 6a-c and 11.Crystallizations of 6a-c from crude 70-80percent pure 5a-c and decomposition of the complexes by ammonia gave the pure diphosphines.Ligand exchange between 6a-c and 2 in methanol at 23 deg C was rapid and complete.Treatment of the resulting solutions with H2 gave active catalysts for asymmetric hydrogenations.
