58358-48-8

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 533-58-4 2-Iodophenol 
• 39110-21-9 [(4-methylphenyl)methylene]triphenylphosphorane 
• 90-02-8 salicylaldehyde 
• 104-82-5 4-Methylbenzyl chloride 
• 624-31-7 4-tolyl iodide 
• 95-56-7 2-hydroxybromobenzene 
• 5720-05-8 4-methylphenylboronic acid 
• 695-84-1 2-allylphenol 
• 104-81-4 4-Methylbenzyl bromide 
• 2378-86-1 4-methylbenzyltriphenylphosphonium bromide 

Downstream Products

• 25664-48-6 2-p-tolyl-benzofuran 
• 58491-51-3 2-(4-methylphenyl)benzofuran-3-carbaldehyde 
• 58491-52-4 2-(4-methylphenyl)benzofuran-3-carboxylic acid 

Relevant academic research and scientific papers

MIDA-Vinylsilanes: Selective Cross-Couplings and Applications to the Synthesis of Functionalized Stilbenes

(Chemical Equation Presented). A rapid and stereodefined synthesis of MIDA-boryl vinylsilanes has been achieved through the hydrosilylation of an alkynylboronic ester. The E products which contain a silyl and boryl group can be selectively cross-coupled i

Preparation and application of 2-(4-substituted phenyl)-3-formamide benzofuranene cyanide compound

The invention provides a preparation and application of a 2-(4-substituted phenyl)-3-formamide benzofuranene cyanide compound. The benzofuranene cyanide compound shown in formula I has a structure shown in the following formula I, wherein the definition o

Hypervalent Iodine(III)-Catalyzed Synthesis of 2-Arylbenzofurans

An alternative route for the synthesis of 2-arylbenzofurans is described by iodine(III)-catalyzed oxidative cyclization of 2-hydroxystilbenes using 10 mol% (diacetoxyiodo)benzene [PhI(OAc) 2 ] as catalyst in the presence of m -chloroperbenzoic acid. The 2-arylbenzofurans were isolated in good to excellent yields.

Synthesis, biological evaluation and molecular docking analysis of 2-phenyl-benzofuran-3-carboxamide derivatives as potential inhibitors of Staphylococcus aureus Sortase A

In Gram-positive bacteria, Sortase A (Srt A) is a critical cysteine transpeptidase that is responsible for recognizing and assembling surface virulence proteins through the recognition of a LPXTG (leucine, proline, X, threonine, and glycine, where X is an

Benzofuran compound, preparation method and applications thereof

The present invention provides a benzofuran compound, a preparation method and applications thereof, wherein the structure is represented by a general formula (I-1) or (I-2), R1, R3 and R4 are any one selected from hydrogen, C1-C5 straight or branched cha

Benzofuran compounds intermediates, and preparation method and application thereof

The invention provides a kind of benzofuran compounds intermediates, and a preparation method and application thereof, and the structure of the intermediates is shown as a general formula (I) in the specification. In the general formula (I), R1 and R3 are

Trans-O-hydroxy-diphenyl ethylene derivatives and its preparation method and application

The invention discloses a trans-o-hydroxy stilbene derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: in the presence of a rhodium catalyst and acetate, reacting an o-hydroxy styrene compound with arylboronic acid in a solvent, and after the reaction is completed, treating, thereby obtaining the trans-o-hydroxy stilbene derivative. The preparation method is mild in reaction conditions, procedures are simple and can be rapidly performed, and the yield is relatively high. The cell experiment shows that compared with resveratrol, a product prepared from the trans-o-hydroxy stilbene derivative is generally better in anti-tumor activity.

Synthesis and antiproliferative evaluation of 2-hydroxylated (E)-stilbenes

A simple synthesis of 2-hydroxylated (E)-stilbenes was accomplished in good yields via oxidative coupling of 2-hydroxystyrenes and arylboronic acids, with Rh(III)-catalyst and Cu(OAc)2 as oxidant. The antiproliferative evaluation of all the synthesized compounds were assessed on four different human cancer cell lines (Colo-205, MDA-468, HT29, and MGC80-3), and the results showed that several compounds exhibit strong antiproliferative activities (up to IC50 = 35 nM for MGC80-3).

Hypervalent iodine mediated oxidative cyclization of o -hydroxystilbenes into benzo- and naphthofurans

A new and convenient metal-free cyclization of ortho-hydroxystilbenes into 2-arylbenzofurans and 2-arylnaphthofurans mediated by hypervalent iodine reagents is described. The cyclization products are isolated in good to excellent yields using stoichiometric (diacetoxyiodo)benzene in acetonitrile. Georg Thieme Verlag Stuttgart New York.

Preparation of (E)-2-Hxdroxy-4'-Substituted Stilbenes

Sixteen (E)-2-hydroxy-4'-substituted stilbenes have been prepared by the Wittig reaction.Direct coupling of the appropriate p-substituted benzylidenetriphenylphosphoranes with salicylaldehyde afforded the (E)-stilbenols (2) 4'-R = H(2a), Me(2b), But(2c), Ph(2d), CN(2e), NO2(2i), OMe(2k), F(2n), Cl(2o), and Br(2p).Alternatively, the Wittig reaction of o-methoxymethoxybenzylidenetriphenylphosphorane with various p-substituted benzaldehydes gave the (E)-methoxymethylstilbenols (4) which upon acidic cleavage furnished the corresponding stilbenols (2) 4'-R = CN(2e), CO2Me(2f), NMe2(2h), OH(2j), OAc(2m), and I(2q).The symmetrical (E)-2,2'-dihydroxystilbene was obtained in an analogous fashion.Reduction of nitrostilbenol (2i) yielded the corresponding aminostilbenol (2g).