5838-57-3Relevant academic research and scientific papers
Additive-free pd-catalyzed α-allylation of imine-containing heterocycles
Kljajic, Marko,Puschnig, Johannes G.,Weber, Hansj?rg,Breinbauer, Rolf
supporting information, p. 126 - 129 (2017/11/27)
An additive-free Pd-catalyzed α-allylation of different imino-group-ontaining heterocycles is reported. The activation of α-CH pronucleophiles (pKa (DMSO) > 25) occurs without the addition of strong bases or Lewis acids using only the Pd/Xantphos catalyst system. The reaction scope has been studied for various 5- and 6-membered nitrogen-containing heterocycles (yields up to 96%). Mechanistic investigations suggest an initial allylation of the imine-N followed by a Pd-catalyzed formal aza-Claisen rearrangement.
Functionalized orthoesters as powerful building blocks for the efficient preparation of heteroaromatic bicycles
Bastug, Gulluzar,Eviolitte, Christophe,Markó, István E.
supporting information; experimental part, p. 3502 - 3505 (2012/08/08)
By combining substituted anilines with functionalized orthoesters, an efficient and connective methodology for the preparation of benzoxazole, benzothiazole, and benzimidazole derivatives has been established. The versatility of this approach enables the development of new libraries of heterocycles containing multifunctional sites.
