583837-90-5

Basic information

• Product Name: 1H-2-Benzopyran-3-carboxylic acid, 6-chloro-1-oxo-4-phenyl-, methyl ester
• CAS NO: 583837-90-5
• Molecular Formula: C17H11ClO4
• Molecular Weight: 314.725
• Mol File: 583837-90-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-2-Benzopyran-3-carboxylic acid, 6-chloro-1-oxo-4-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-2-Benzopyran-3-carboxylic acid, 6-chloro-1-oxo-4-phenyl-, methyl ester(583837-90-5)
• EPA Substance Registry System: 1H-2-Benzopyran-3-carboxylic acid, 6-chloro-1-oxo-4-phenyl-, methyl ester(583837-90-5)

Safety Data

• Hazardous Substances Data: 583837-90-5(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 33184-56-4 2-benzoyl-4-chlorobenzoic acid 
• 118-45-6 4-chlorophthalic anhydride 
• 67-56-1 methanol 
• 142256-41-5 6-chloro-1-oxo-4-phenyl-1H-isochromene-3-carboxylic acid 

Downstream Products

• 583831-77-0 6-chloro-2-methylamino-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester 

Relevant articles and documents

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)

A novel series of 4-phenylisoquinolones were synthesized and evaluated as c-Jun N-terminal kinase (JNK) inhibitors. Initial modification at the 2- and 3-positions of the isoquinolone ring of hit compound 4, identified from high-throughput screening, led to the lead compound 6b. The optimization was carried out using a JNK1-binding model of 6b and several compounds exhibited potent JNK inhibition. Among them, 11g significantly inhibited cardiac hypertrophy in rat pressure-overload models without affecting blood pressure and the concept of JNK inhibitors as novel therapeutic agents for heart failure was confirmed.