58413-22-2Relevant academic research and scientific papers
Synthesis, docking studies and anti-inflammatory activity of 4,5,6,7-tetrahydro-2H-indazole derivatives
Rosati, Ornelio,Curini, Massimo,Marcotullio, Maria Carla,Macchiarulo, Antonio,Perfumi, Marina,Mattioli, Laura,Rismondo, Francesco,Cravotto, Giancarlo
, p. 3463 - 3473 (2007)
A regioselective synthesis of 2,3-disubstituted tetrahydro-2H-indazols, mediated by α-zirconium sulfophenylphosphonate-methanephosphonate, was reported. Docking studies into the catalytic site of COX-2 were used to identify potential anti-inflammatory lea
Microwave-assisted synthesis, biological assessment, and molecular modeling of aza-heterocycles: Potential inhibitory capacity of cholinergic enzymes to Alzheimer's disease
Galdámez, Antonio,Gutiérrez, Margarita,Henao, José A.,Morales-Bayuelo, Alejandro,Nú?ez, Yeray A. Rodríguez,Polo, Efraín,Prent-Pe?aloza, Luis,Ramos, Juan,Trilleras, Jorge,Valdés-Salas, Lady
, (2020/10/02)
A highly regioselective solvent-free microwave-assisted synthesis of pyrazoles and tetrahydroindazoles based on the condensation of 1,3-diketones with arylhydrazines is described. Compounds were evaluated as cholinesterase inhibitors in order to identify
Synthesis of hydrogenated indazole derivatives starting with α,β-unsaturated ketones and hydrazine derivatives
Nakhai, Azadeh,Bergman, Jan
experimental part, p. 2298 - 2306 (2009/07/11)
The reaction of hydrazine derivatives with α,β-unsaturated ketones, such as cyclohexenyl(phenyl)methanone and (E)-2-benzylidenecyclohexanone, were investigated. The reaction between methylhydrazine and e.g., cyclohexenyl(phenyl)methanone was particularly interesting as 3a,4,5,6,7,7a-hexahydro-1-methyl-3-phenyl-1H-indazole was obtained as the major product together with 4,5,6,7-tetrahydro-2-methyl-3-phenyl-2H-indazole as a minor product.
Palladium-catalyzed coupling of pyrazole triflates with arylboronic acids
Dvorak, Curt A.,Rudolph, Dale A.,Ma, Sandy,Carruthers, Nicholas I.
, p. 4188 - 4190 (2007/10/03)
A general protocol for the palladium-mediated Suzuki coupling reaction of pyrazole inflates and aryl boronic acids has been developed. The use of additional dppf ligand was determined to increase product yields allowing for the use of a broad range of rea
Facile synthesis of 2H-indazole derivatives starting from the Baylis-Hillman adducts of 2-cyclohexen-1-one
Lee, Ka Young,Gowrisankar, Saravanan,Kim, Jae Nyoung
, p. 5387 - 5391 (2007/10/03)
Facile synthetic method of 2H-indazole derivatives was developed involving DDQ oxidation of pyrazoles, which were prepared starting from the Baylis-Hillman adducts of 2-cyclohexen-1-one.
Regioselective synthesis of 1,3,4,5-tetrasubstituted pyrazoles from Baylis-Hillman adducts
Lee, Ka Young,Kim, Jeong Mi,Kim, Jae Nyoung
, p. 6737 - 6740 (2007/10/03)
Tetrasubstituted pyrazole derivatives 3a-j were synthesized regioselectively in good yields from the reaction of Baylis-Hillman adducts 1a-f and hydrazine hydrochlorides 2a-d in 1,2-dichloroethane.
1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2
Sui, Zhihua,Guan, Jihua,Ferro, Michael P.,McCoy, Kathy,Wachter, Michael P.,Murray, William V.,Singer, Monica,Steber, Michele,Ritchie, Dave M.,Argentieri, Dennis C.
, p. 601 - 604 (2007/10/03)
Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution pattern of the pyrazole ring in 1 differentiates these compounds from most of the known selective COX-2 inhibitors that contain two aryl rings at the adjacent positions on a heterocyclic or a phenyl ring. Similarly, the two phenyl rings in 2 are also separated by three atoms. SAR of both phenyl rings in 1 and 2, and the aliphatic ring in 1 will be discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.
