58458-13-2

Basic information

• Product Name: 2-bromo-6-(trifluoromethyl)aniline
• Synonyms: 2-bromo-6-(trifluoromethyl)aniline;Einecs 261-262-1;2-Amino-3-bromobenzotrifluoride 98%;2-Amino-3-bromobenzotrifluoride98%
• CAS NO: 58458-13-2
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.0205096
• EINECS: 261-262-1
• Mol File: 58458-13-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 215.6 °C at 760 mmHg
• Flash Point: 84.2 °C
• Appearance: /
• Density: 1.697 g/cm³
• Vapor Pressure: 0.146mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.60±0.10(Predicted)
• CAS DataBase Reference: 2-bromo-6-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-6-(trifluoromethyl)aniline(58458-13-2)
• EPA Substance Registry System: 2-bromo-6-(trifluoromethyl)aniline(58458-13-2)

Safety Data

• Hazardous Substances Data: 58458-13-2(Hazardous Substances Data)

Usage

General Description

2-bromo-6-(trifluoromethyl)aniline is a chemical compound with the molecular formula C7H5BrF3N. It is a bromo-substituted aniline derivative with a trifluoromethyl group attached to the carbon ring. 2-bromo-6-(trifluoromethyl)aniline is commonly used in pharmaceutical and agrochemical research as a building block for the synthesis of complex organic molecules. It is also used in the production of dyes and pigments. 2-bromo-6-(trifluoromethyl)aniline is a potentially hazardous chemical that should be handled with care and according to proper safety protocols.

InChI:InChI=1/C7H5BrF3N/c8-5-3-1-2-4(6(5)12)7(9,10)11/h1-3H,12H2

Upstream product

• 887144-94-7 Togni's reagent II 
• 615-36-1 2-bromoaniline 
• 121-01-7 4-nitro-2-trifluoromethyl-aniline 
• 85977-22-6 N-(2-bromo-6-(trifluoromethyl)phenyl)acetamide 
• 85977-20-4 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide 
• 85977-21-5 2-Bromo-4-amino-6-(trifluoromethyl)acetanilide 
• 400-66-8 2-bromo-4-nitro-6-trifluoromethylaniline 

Downstream Products

• 58458-14-3 2-amino-3-trifluoromethylbenzonitrile 
• 1429256-84-7 C₁₇H₁₈BrF₅N₂O₂ 
• 85977-23-7 1-Bromo-2-iodo-3-(trifluoromethyl)benzene 

Relevant articles and documents

Transition metal-free direct C–H trifluoromethyltion of (hetero)arenes with Togni's reagent

A new transition-metal-free direct C–H trifluoromethylation reaction of (hetero)arenes with Togni's reagent was developed. This transformation proceeded smoothly under mild conditions and exhibited good tolerance of many synthetically relevant functional groups. It provided an alternative approach for the synthesis of trifluoromethylated (hetero)arenes.

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

Substituted cyano,trifluoromethylphenyl linear triazenes

The compounds of this invention are substituted cyano,trifluoromethylphenyl linear triazenes having pharmacological activity. In particular, these compounds have anorectic and anti-obesity activity. A preferred compound is 1,3-bis(2-cyano-5-trifluoromethylphenyl)triazene.