58481-18-8

Basic information

• Product Name: 2-Acetylaminomethyl pyridine
• Synonyms: 2-Acetylaminomethyl pyridine;n-pyridin-2-ylmethyl-acetamide
• CAS NO: 58481-18-8
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.1778
• Mol File: 58481-18-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Acetylaminomethyl pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetylaminomethyl pyridine(58481-18-8)
• EPA Substance Registry System: 2-Acetylaminomethyl pyridine(58481-18-8)

Safety Data

• Hazardous Substances Data: 58481-18-8(Hazardous Substances Data)

Usage

Chemical Structure

Contains a pyridine ring with an acetylaminomethyl group attached

Usage in Pharmaceutical Industry

Acts as an intermediate for synthesizing various pharmaceutical drugs

Potential as a Ligand

Studied for its suitability as a ligand in coordination chemistry

Antimicrobial Properties

Investigated for its antimicrobial effects

Interest in Organic Chemistry

Attracts attention due to its unique chemical structure

Potential Applications

Holds promise for further research and potential applications

Upstream product

• 60-35-5 acetamide 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 562-90-3 tetraacetoxysilane 
• 4814-80-6 acetylaminoacetonitrile 
• 74-86-2 acetylene 

Downstream Products

• 6558-63-0 3-methylimidazo<1,5-a>pyridine 
• 147236-25-7 N-acetyl-3-(1,1-dimethylethyl)-4-hydroxy-N-(2-pyridinylmethyl)benzamide 
• 147219-66-7 4-<carbonyl>-2-(1,1-dimethylethyl)phenyl octadecylcarbamate 
• 53175-17-0 N-((1-oxy-pyridin-2-yl)methyl)acetamide 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 934339-98-7 acetonitrile(N-(2-pyridylmethyl)acetamide)(triphenylphosphine)copper(I) hexafluorophosphate 
• 147236-55-3 N-Acetyl-N-(2-pyridinylmethyl)-3,4-bis(tetradecyloxy)benzamide 
• 147236-53-1 N-Acetyl-3-methoxy-4-(tetradecyloxy)-N-(2-pyridinylmethyl)benzamide 

Relevant articles and documents

Metal-Free C-C Coupling of an Allenyl Sulfone with Picolyl Amides to Access Vinyl Sulfones via Pyridine-Initiated in Situ Generation of Sulfinate Anion

Vinyl sulfones are privileged motifs known for their biological activity and synthetic utility. Synthetic transformations to efficiently access high-value compounds with these motifs are desired and sought after. Herein, a new procedure is described to fo

New half-sandwich (η6-p-cymene)ruthenium(II) complexes with benzothiazole hydrazone Schiff base ligand: Synthesis, structural characterization and catalysis in transamidation of carboxamide with primary amines

Few half-sandwich (η6-p-cymene) ruthenium(II) complexes supported by benzothiazole hydrazone Schiff bases were synthesized. The new complexes possess the general formulae [Ru(η6-p-cymene)(L)Cl] (1-3) (L = salicyl((2-(benzothiazol-2-yl)hydrazono)methylphenol) (SAL-HBT), 2-((2-(benzothiazol-2-yl)hydrazono)methyl)-6 methoxyphenol) (VAN-HBT) or naphtyl-2-((2-(benzothiazol-2-yl)hydrazono)methyl phenol) (NAP-HBT). All compounds were fully studied by analytical, spectroscopic techniques (IR, NMR) and also by mass spectrometry. The solid state structure of the complex 3 reveals the coordination of p-cymene moieties with ruthenium(II) in a three-legged piano-stool geometry along with benzothiazole hydrazone Schiff base ligand in a monobasic bidentate fashion. The catalytic properties of the complexes were screened in transamidation of primary amide with amines after optimization with respect to solvent, substituents, time and catalyst loading. The results show that the complex 3 is the most efficient catalyst for the transamidation of carboxamides with amines.

Efficient Preparation of Imidazo[1,5- a ]pyridine-1-carboxylic Acids

We report a novel and efficient approach to the synthesis of imidazo[1,5-a]pyridine-1-carboxylic acids. By using the reaction of 2-(aminomethyl)pyridine with acyl chlorides followed by one-pot treatment with trifluoroacetic anhydride, 2,2,2-trifluoro-1-im