58518-73-3

Upstream product

• 139-59-3 4-phenoxyanilin 
• 100-00-5 4-chlorobenzonitrile 
• 6312-87-4 p-phenoxyacetanilide 
• 21969-05-1 1-(4-nitrophenoxy)-4-iodobenzene 
• 620-88-2 4-nitrophenyl phenyl ether 
• 860578-02-5 acetic acid-[4-(4-iodo-phenoxy)-anilide] 

Downstream Products

• 876914-26-0 4-(4'-methoxy-biphenyl-4-yloxy)-phenylamine 
• 148120-09-6 2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(4'-iodophenoxy)-phenyl]-prop-2-enamide 
• 28896-49-3 bis(4-iodophenyl) ether 

Relevant academic research and scientific papers

METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY

The present invention relates to compounds which modulate the activity of the SI P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1 P1 receptor, and pharmaceutical compositions comprising these compounds.

3-cycloalkyl-prop-2-enamides

A compound selected from the group consisting of a compound of the formula STR1 wherein R1 is hydrogen or alkyl of 1 to 3 carbon atoms, W is selected from the group consisting of --O--, --S--, --SO-- and --SO2 --, Z and Y are --CH-- or one is --CH-- and the other is --N--, R2, R3, R4, R5 and R6 are individually selected from the group consisting of hydrogen, halogen, methoxy, methylthio, alkyl of 1 to 4 carbon atoms, --WCF3, --CF3, --NO2, --CN--, --W--(CH2)n --CF3, --W--(CF2)n --CF3, --(CF2)n --CF3 and --(CH2)n --CX3, is an integer from 1 to 3, X is a halogen or R3 and R4 together are --O--(CH2)--O-- and R2, R5 and R6 are as defined above, R7 and R8 are individually hydrogen or alkyl of 1 to 6 carbon atoms, R9 is cycloalkyl of 3 to 6 carbon atoms and their non-toxic, pharmaceutically acceptable salts with bases.