28896-49-3

Basic information

• Product Name: 4-IODOPHENYL ETHER
• Synonyms: 4,4'-Diiododiphenyl ether;Benzene, 1,1'-oxybis(4-iodo-;Bis(p-iodophenyl) ether;Ether, bis(p-iodophenyl);ether,bis(p-iodophenyl);4-IODOPHENYL ETHER;2-Iodo-4,5-dimethylnitrobenzene;Benzene, 1,1'-oxybis[4-iodo- Ether, bis(p-iodophenyl)
• CAS NO: 28896-49-3
• Molecular Formula: C₁₂H₈I₂O
• Molecular Weight: 422
• Mol File: 28896-49-3.mol
• Article Data: 26

Chemical Properties

• Melting Point: 43-45°C
• Boiling Point: 377.5 °C at 760 mmHg
• Flash Point: 182.1 °C
• Appearance: /
• Density: 2.066 g/cm³
• Vapor Pressure: 0.00071mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 4-IODOPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODOPHENYL ETHER(28896-49-3)
• EPA Substance Registry System: 4-IODOPHENYL ETHER(28896-49-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 28896-49-3(Hazardous Substances Data)

Usage

Description

4-Iodophenyl Ether, also known as p-Iodophenyl Ether or 4-Iododiphenyl Ether, is a chemical compound characterized by the presence of an iodine atom and an ether group. With a chemical formula of C12H9IO, it has a molar mass of 344.10 g/mol. Due to its hazardous nature, it is not commonly found in regular consumer products and is primarily used in scientific or industrial settings. 4-IODOPHENYL ETHER is known for its relatively high reactivity, which is attributed to the iodine atom. It is essential to handle this material with caution, as it can cause harm to the eyes, respiratory system, and skin upon exposure. Proper training is recommended for safe handling.

Uses

Used in Scientific Research:
4-Iodophenyl Ether is used as a reagent in various scientific research applications due to its high reactivity. The presence of the iodine atom allows for unique chemical reactions that can be harnessed in the synthesis of other compounds or for studying chemical properties.
Used in Industrial Applications:
In the industrial sector, 4-Iodophenyl Ether is employed as an intermediate in the production of certain specialty chemicals. Its reactivity and unique chemical structure make it a valuable component in the synthesis of specific industrial products.
Used in Pharmaceutical Development:
4-Iodophenyl Ether is used as a building block in the development of pharmaceutical compounds. Its reactivity and structural properties can be utilized to create new drug molecules with potential therapeutic applications.
Used in Material Science:
In the field of material science, 4-Iodophenyl Ether is used as a component in the synthesis of advanced materials with specific properties. Its unique chemical structure can contribute to the development of new materials with improved performance characteristics.

InChI:InChI=1/C12H9IO/c13-10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9H

Upstream product

• 101-84-8 diphenylether 
• 2974-94-9 4-phenoxyiodobenzene 
• 624-38-4 para-diiodobenzene 
• 58518-73-3 4-(4-iodo-phenoxy)-aniline 
• 6312-87-4 p-phenoxyacetanilide 
• 139-59-3 4-phenoxyanilin 
• 100-00-5 4-chlorobenzonitrile 
• 860578-02-5 acetic acid-[4-(4-iodo-phenoxy)-anilide] 
• 21969-05-1 1-(4-nitrophenoxy)-4-iodobenzene 
• 620-88-2 4-nitrophenyl phenyl ether 
• 7790-99-0 Iodine monochloride 
• 64-19-7 acetic acid 

Downstream Products

• 5024-85-1 4,4'-bis(4-dimethoxyphenoxyl)phenyl ether 
• 855126-43-1 3-[4-(4-iodo-phenoxy)-phenoxy]-1-aza-bicyclo[2.2.2]octane 
• 101-80-4 4,4'-oxydiphenylene diamine 
• 943035-24-3 4-[4-(4-iodophenoxy)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1965-09-9 4,4'-dihydroxydiphenyl ether 
• 15051-28-2 4,4'-bis[4-(4-hydroxyphenoxy)phenoxy]diphenyl ether 
• 5024-81-7 4,4'-(bis(p-hydroxyphenoxy))diphenyl ether 
• 21368-80-9 1,1'-oxybis(4-ethynylbenzene) 
• 17541-14-9 4,4'-bis(3-hydroxy-3-methylbutynyl)diphenyl ether 
• 916265-23-1 4,4'-bis[4-{4-(methoxymethoxy)phenoxy}phenoxy]diphenyl ether 
• 83281-31-6 4,4'-distyryldiphenyl ether 

Relevant articles and documents

R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond

A new convenient and versatile halogenating system (R4NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES

The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases

IBX-I2 redox couple for facile generation of IOH and I +: Expedient protocol for iodohydroxylation of olefins and iodination of aromatics

(Chemical Equation Presented) IBX is readily reduced to IBAin the presence of molecular iodine in DMSO to generate hypoiodous acid (IOH), which reacts with a variety of olefins as well as R, β-unsaturated ketones leading to their respective iodohydrins with anti stereochemistry. The same redox chemistry in acetonitrile containing TFA produces iodonium ions for facile iodination of a variety of aromatic compounds in respectable isolated yields.