28896-49-3

Basic information

• Product Name: 4-IODOPHENYL ETHER
• Synonyms: 4,4'-Diiododiphenyl ether;Benzene, 1,1'-oxybis(4-iodo-;Bis(p-iodophenyl) ether;Ether, bis(p-iodophenyl);ether,bis(p-iodophenyl);4-IODOPHENYL ETHER;2-Iodo-4,5-dimethylnitrobenzene;Benzene, 1,1'-oxybis[4-iodo- Ether, bis(p-iodophenyl)
• CAS NO: 28896-49-3
• Molecular Formula: C₁₂H₈I₂O
• Molecular Weight: 422
• Mol File: 28896-49-3.mol

Chemical Properties

• Melting Point: 43-45°C
• Boiling Point: 377.5 °C at 760 mmHg
• Flash Point: 182.1 °C
• Appearance: /
• Density: 2.066 g/cm³
• Vapor Pressure: 0.00071mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 4-IODOPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODOPHENYL ETHER(28896-49-3)
• EPA Substance Registry System: 4-IODOPHENYL ETHER(28896-49-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 28896-49-3(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
4-Iodophenyl Ether is used as a reagent in various scientific research applications due to its high reactivity. The presence of the iodine atom allows for unique chemical reactions that can be harnessed in the synthesis of other compounds or for studying chemical properties.
Used in Industrial Applications:
In the industrial sector, 4-Iodophenyl Ether is employed as an intermediate in the production of certain specialty chemicals. Its reactivity and unique chemical structure make it a valuable component in the synthesis of specific industrial products.
Used in Pharmaceutical Development:
4-Iodophenyl Ether is used as a building block in the development of pharmaceutical compounds. Its reactivity and structural properties can be utilized to create new drug molecules with potential therapeutic applications.
Used in Material Science:
In the field of material science, 4-Iodophenyl Ether is used as a component in the synthesis of advanced materials with specific properties. Its unique chemical structure can contribute to the development of new materials with improved performance characteristics.

InChI:InChI=1/C12H9IO/c13-10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9H

Upstream product

• 2974-94-9 4-phenoxyiodobenzene 
• 58518-73-3 4-(4-iodo-phenoxy)-aniline 
• 101-84-8 diphenylether 
• 7790-99-0 Iodine monochloride 
• 64-19-7 acetic acid 
• 624-38-4 para-diiodobenzene 
• 860578-02-5 acetic acid-[4-(4-iodo-phenoxy)-anilide] 
• 6312-87-4 p-phenoxyacetanilide 
• 21969-05-1 1-(4-nitrophenoxy)-4-iodobenzene 
• 620-88-2 4-nitrophenyl phenyl ether 
• 139-59-3 4-phenoxyanilin 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 83281-31-6 4,4'-distyryldiphenyl ether 
• 916265-23-1 4,4'-bis[4-{4-(methoxymethoxy)phenoxy}phenoxy]diphenyl ether 
• 21368-80-9 1,1'-oxybis(4-ethynylbenzene) 
• 943035-24-3 4-[4-(4-iodophenoxy)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 101-80-4 4,4'-oxydiphenylene diamine 
• 1965-09-9 4,4'-dihydroxydiphenyl ether 
• 855126-43-1 3-[4-(4-iodo-phenoxy)-phenoxy]-1-aza-bicyclo[2.2.2]octane 
• 15051-28-2 4,4'-bis[4-(4-hydroxyphenoxy)phenoxy]diphenyl ether 
• 5024-81-7 4,4'-(bis(p-hydroxyphenoxy))diphenyl ether 
• 17541-14-9 4,4'-bis(3-hydroxy-3-methylbutynyl)diphenyl ether 
• 5024-85-1 4,4'-bis(4-dimethoxyphenoxyl)phenyl ether 

Relevant articles and documents

R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond

A new convenient and versatile halogenating system (R4NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

Mass production method of 4,4'-oxydianiline from 1,4-diiodobenzene

The present invention relates to a method for producing 4,4andprime;-oxydianiline using 1,4-diiodobenzene. After 4,4andprime;-oxybis (iodobenzene) is produced by using a Cu catalyst and 1,4-diiodobenzene in a polar solvent mixed with water, 4,4andprime;-oxydianiline can be produced through amination with ammonia introduced without a separate purification process. Therefore, compared to the conventional invention, there is an advantage in that 4,4andprime;-oxydianiline can be directly produced through amination without an intermediate purification process. In addition, expensive iodine used in the reaction is recovered as ammonium iodide and can be used again to produce 1,4-diiodobenzene, so the process efficiency is high.COPYRIGHT KIPO 2020

COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES

The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases

IAP inhibitor and its preparation and use (by machine translation)

The invention of formula (I) compound and its pharmaceutically acceptable salt. Such compounds can be used for inhibiting IAP, thus can be used for the treatment of the IAP-mediated diseases, such as cancer, autoimmune diseases, and viral diseases. The invention also relates to pharmaceutical compositions of such compounds, the method of preparing such compounds and the compound or pharmaceutical composition in preparation for the treatment of cancer by the IAP-mediated, autoimmune diseases, and viral diseases in the application. (by machine translation)

IBX-I2 redox couple for facile generation of IOH and I +: Expedient protocol for iodohydroxylation of olefins and iodination of aromatics

(Chemical Equation Presented) IBX is readily reduced to IBAin the presence of molecular iodine in DMSO to generate hypoiodous acid (IOH), which reacts with a variety of olefins as well as R, β-unsaturated ketones leading to their respective iodohydrins with anti stereochemistry. The same redox chemistry in acetonitrile containing TFA produces iodonium ions for facile iodination of a variety of aromatic compounds in respectable isolated yields.

1,3-Diiodo-5,5-dimethylhydantoin-An efficient reagent for iodination of aromatic compounds

1,3-Diiodo-5,5-dimethylhydantoin in organic solvents successfully iodinates alkylbenzenes, aromatic amines, and phenyl ethers. The reactivity of electrophilic iodine is controlled by acidity of the medium. Superelectrophilic iodine generated upon dissolution of 1,3-diiodo-5,5-dimethylhydantoin in sulfuric acid readily reacts with electron-deficient arenes at 0 to 20°C with formation of the corresponding iodo derivatives in good yields. The structure of electrophilic iodine species generated from 1,3-diiodo-5,5- dimethylhydantoin in sulfuric acid is discussed.

Synthesis and structure of cyclic oligo(p-phenylene oxide)s, -(C 6H4O)n- (n = 6-10)

Stepwise growth of oligo(p-phenylene oxide)s and cyclization via the Ullmann coupling reaction by using CuI/N,N-dimethylglycine afforded cyclic oligo(p-phenyleneoxide)s, -(C6H4O)n-(n = 6-10). The structure of the new cyclophanes was determined by X-ray crystallography, which revealed that they have planar or slightly bent structures with diameters of 1.0-1.5 nm.

Synthesis of ethynyl end-capped oligo-aryl ethers

A series of aryl ether oligomers end-capped with ethynyl groups have been synthesised via a three-step process, i.e. iodination of oligo-aryl ethers, nucleophilic substitution of the iodide group with 2-methyl-3-butyn-2-ol catalysed by Pd/Cu and subsequen

Solid-phase iodination of arenes with the system iodine-diacetoxy(phenyl)- λ3-iodane

The system iodine-diacetoxy(phenyl)-λ3-iodane in the solid phase is capable of iodinating activated arenes.

Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds using iodine and bromine

Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds with iodine and bromine or their sodium salts proceed well in the presence of Fe(NO3) 3·1.5N2O4/charcoal in CH 2Cl2 at room temperature.