28896-49-3Relevant articles and documents
R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond
Bondarenko, Oksana B.,Karetnikov, Georgy L.,Komarov, Arseniy I.,Pavlov, Aleksandr I.,Nikolaeva, Svetlana N.
supporting information, p. 322 - 332 (2021/01/14)
A new convenient and versatile halogenating system (R4NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.
Mass production method of 4,4'-oxydianiline from 1,4-diiodobenzene
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Paragraph 0024-0025; 0027-0037, (2020/07/02)
The present invention relates to a method for producing 4,4andprime;-oxydianiline using 1,4-diiodobenzene. After 4,4andprime;-oxybis (iodobenzene) is produced by using a Cu catalyst and 1,4-diiodobenzene in a polar solvent mixed with water, 4,4andprime;-oxydianiline can be produced through amination with ammonia introduced without a separate purification process. Therefore, compared to the conventional invention, there is an advantage in that 4,4andprime;-oxydianiline can be directly produced through amination without an intermediate purification process. In addition, expensive iodine used in the reaction is recovered as ammonium iodide and can be used again to produce 1,4-diiodobenzene, so the process efficiency is high.COPYRIGHT KIPO 2020
COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES
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Paragraph 0900; 0901, (2019/07/23)
The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases
IAP inhibitor and its preparation and use (by machine translation)
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Paragraph 0176-0180, (2018/03/24)
The invention of formula (I) compound and its pharmaceutically acceptable salt. Such compounds can be used for inhibiting IAP, thus can be used for the treatment of the IAP-mediated diseases, such as cancer, autoimmune diseases, and viral diseases. The invention also relates to pharmaceutical compositions of such compounds, the method of preparing such compounds and the compound or pharmaceutical composition in preparation for the treatment of cancer by the IAP-mediated, autoimmune diseases, and viral diseases in the application. (by machine translation)
IBX-I2 redox couple for facile generation of IOH and I +: Expedient protocol for iodohydroxylation of olefins and iodination of aromatics
Moorthy, Jarugu Narasimha,Senapati, Kalyan,Kumar, Sarvesh
supporting information; experimental part, p. 6287 - 6290 (2009/12/08)
(Chemical Equation Presented) IBX is readily reduced to IBAin the presence of molecular iodine in DMSO to generate hypoiodous acid (IOH), which reacts with a variety of olefins as well as R, β-unsaturated ketones leading to their respective iodohydrins with anti stereochemistry. The same redox chemistry in acetonitrile containing TFA produces iodonium ions for facile iodination of a variety of aromatic compounds in respectable isolated yields.
1,3-Diiodo-5,5-dimethylhydantoin-An efficient reagent for iodination of aromatic compounds
Chaikovskii,Filimonov,Funk,Skorokhodov,Ogorodnikov
, p. 1291 - 1296 (2008/03/27)
1,3-Diiodo-5,5-dimethylhydantoin in organic solvents successfully iodinates alkylbenzenes, aromatic amines, and phenyl ethers. The reactivity of electrophilic iodine is controlled by acidity of the medium. Superelectrophilic iodine generated upon dissolution of 1,3-diiodo-5,5-dimethylhydantoin in sulfuric acid readily reacts with electron-deficient arenes at 0 to 20°C with formation of the corresponding iodo derivatives in good yields. The structure of electrophilic iodine species generated from 1,3-diiodo-5,5- dimethylhydantoin in sulfuric acid is discussed.
Synthesis and structure of cyclic oligo(p-phenylene oxide)s, -(C 6H4O)n- (n = 6-10)
Takeuchi, Daisuke,Asano, Itaru,Osakada, Kohtaro
, p. 8614 - 8617 (2007/10/03)
Stepwise growth of oligo(p-phenylene oxide)s and cyclization via the Ullmann coupling reaction by using CuI/N,N-dimethylglycine afforded cyclic oligo(p-phenyleneoxide)s, -(C6H4O)n-(n = 6-10). The structure of the new cyclophanes was determined by X-ray crystallography, which revealed that they have planar or slightly bent structures with diameters of 1.0-1.5 nm.
Synthesis of ethynyl end-capped oligo-aryl ethers
Xu, Jinfeng,Lai, Guo-Qiao,Wang, Cheng-Yun,Shen, Yong-Jia
, p. 572 - 574 (2007/10/03)
A series of aryl ether oligomers end-capped with ethynyl groups have been synthesised via a three-step process, i.e. iodination of oligo-aryl ethers, nucleophilic substitution of the iodide group with 2-methyl-3-butyn-2-ol catalysed by Pd/Cu and subsequen
Solid-phase iodination of arenes with the system iodine-diacetoxy(phenyl)- λ3-iodane
Krasnokutskaya,Trusova,Filimonov
, p. 1750 - 1751 (2007/10/03)
The system iodine-diacetoxy(phenyl)-λ3-iodane in the solid phase is capable of iodinating activated arenes.
Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds using iodine and bromine
Firouzabadi,Iranpoor,Shiri
, p. 8781 - 8785 (2007/10/03)
Direct and regioselective iodination and bromination of benzene, naphthalene and other activated aromatic compounds with iodine and bromine or their sodium salts proceed well in the presence of Fe(NO3) 3·1.5N2O4/charcoal in CH 2Cl2 at room temperature.