58532-77-7Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF
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Paragraph 0200-0202, (2014/04/03)
The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide y Y2 receptor
Swanson, Devin M.,Wong, Victoria D.,Jablonowski, Jill A.,Shah, Chandra,Rudolph, Dale A.,Dvorak, Curt A.,Seierstad, Mark,Dvorak, Lisa K.,Morton, Kirsten,Nepomuceno, Diane,Atack, John R.,Bonaventure, Pascal,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 5552 - 5556 (2011/10/12)
A series of small molecules based on a chemotype identified from our compound collection were synthesized and tested for binding affinity (IC 50) at the human Neuropeptide Y Y2 receptor (NPY Y 2). Six of the 23 analogs tes
SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
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Page/Page column 27, (2010/11/27)
The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
