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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Phosphinic acid, (hydroxymethyl)phenyl-, ethyl ester serves as a crucial intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used as a Chelating Agent:
In chemical processes, Phosphinic acid, (hydroxymethyl)phenyl-, ethyl ester acts as a chelating agent, forming stable complexes with metal ions, which is beneficial for applications requiring the stabilization or sequestration of metal ions.
Used in Industrial Processes:
Phosphinic acid, (hydroxymethyl)phenyl-, ethyl ester is utilized as a stabilizer or inhibitor in certain industrial applications, enhancing the performance and stability of products in various sectors.

Upstream product

• 50-00-0 formaldehyd 
• 172487-18-2 ethyl Phenylphosphinate 
• 63563-83-7 bis(phthalimidylethyl)amine 
• 62740-39-0 Phenyl O-ethylphosphonite 

Downstream Products

• 172487-18-2 ethyl Phenylphosphinate 

Relevant academic research and scientific papers

Chemistry of the versatile (hydroxymethyl)phosphinyl P(O)CH2OH functional group

(Hydroxymethyl)phosphorus compounds are well-known and valuable compounds in general; however the use of (hydroxymethyl)phosphinates R1P(O) (OR2)CH2OH in particular has been much more limited. The potential of this functio

Lanthanide(III) Complexes of Novel Mixed Carboxylic-Phosphorus Acid Derivatives of Diethylenetriamine: A Step towards More Efficient MRI Contrast Agents

Three novel phosphorus-containing analogues of H5DTPA (DTPA = diethylenetriaminepentaacetate) were synthesised (H6L1, H5L2, H5L3). These compounds have a -CH2-P(O)(OH)-R function (R = OH, Ph, CH2NBn2) attached to the central nitrogen atom of the diethylenetriamine backbone. An NMR study reveals that these ligands bind to lanthanide(III) ions in an octadentate fashion through the three nitrogen atoms, a P-O oxygen atom and four carboxylate oxygen atoms. The complexed ligand occurs in several enantiomeric forms due to the chirality of the central nitrogen atom and the phosphorus atom upon coordination. All lanthanide complexes studied have one coordinated water molecule. The residence times (τM 298) of the coordinated water molecules in the gadolinium(III) complexes of H6L1 and H5L2 are 88 and 92 ns, respectively, which are close to the optimum. This is particularly important upon covalent and noncovalent attachment of these Gd3+ chelates to polymers. The relaxivity of the complexes studied is further enhanced by the presence of at least two water molecules in the second coordination sphere of the Gd3+ ion, which are probably bound to the phosphonate/phosphinate moiety by hydrogen bonds. The complex [Gd(L 3)(H2O)]2- shows strong binding ability to HSA, and the adduct has a relaxivity comparable to MS-325 (40 s-1mM -1 at 40MHz, 37°C) even though it has a less favourable τM value (685 ns). Transmetallation experiments with Zn 2+ indicate that the complexes have a kinetic stability that is comparable to-or better than-those of [Gd(dtpa)(H2O)]2- and [Gd(dtpa-bma)(H2O)].

Enzymatic reactions in ionic liquids: Lipase-catalysed kinetic resolution of racemic, P-chiral hydroxymethanephosphinates and hydroxymethylphosphine oxides

Lipase-mediated acetylation of racemic P-chiral hydroxymethanephosphinates and hydroxymethylphosphine oxides was performed in ionic liquids under kinetic resolution conditions. Lipase AK (Amano) and lipase from Pseudomonas fluorescens (Fluka) were up to s