58566-44-2

Usage

InChI:InChI=1/C11H15NO3/c13-8-6-12(7-9-14)11(15)10-4-2-1-3-5-10/h1-5,13-14H,6-9H2

Upstream product

• 98-88-4 benzoyl chloride 
• 111-42-2 2,2'-iminobis[ethanol] 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 63056-93-9 N,n-bis(2-lauroyloxyethyl)benzamide 

Relevant academic research and scientific papers

Preparation method of organic intermediate N, N-bis (beta-ethoxyl) benzamide

The invention discloses a preparation method of N, N-bis (beta-ethoxyl) benzamide. The preparation method comprises the following steps: step 1, preparing materials: preparing methyl benzoate, N, N-diethanol amine, a catalyst and a mixed solvent according to a mass ratio of 1: (0.77-1.16): (0.011-0.055): (1.10-2.57), taking the methyl benzoate and the N, N-diethanol amine as raw materials, and stirring to obtain a mixed solution; and performing a condensation reaction in the presence of the catalyst, wherein the condensation reaction temperature is 80-95 DEG C, and the condensation reaction time is 5-9 h; and 2, after the reaction is finished, cooling to 50 DEG C, adding the mixed solvent into a reaction kettle, filtering out the catalyst, cooling the filtrate to 0-3 DEG C, crystallizing,filtering and drying to obtain the white powdery solid N, N-di (beta-ethoxyl) benzamide product. The separation and purification process for synthesizing the N, N-di (beta-ethoxyl) benzamide is simple; the reaction time is moderate, the product yield is high, the product yield reaches 95% or above, the product purity is high, the energy consumption is low, the environmental pollution is small, thecost is low, and the method is an ideal process for realizing industrial production.

Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

High-load, oligomeric phosphonyl dichloride: facile generation via ROM polymerization and application to scavenging amines

A new ROMP-derived scavenging reagent, oligomeric phosphonyl dichloride (OPC), with high-load and selectivity is reported. This reagent can be readily generated via the ROM polymerization of bicyclo[2.2.1]hept-5-en-2-ylphosphonic dichloride, which is conveniently assembled from the Diels-Alder reaction of cyclopentadiene and vinyl phosphonic dichloride. The OPC has been exploited in the rapid, efficient scavenging of primary and secondary amines that are present in excess following a common benzoylation event at room temperature (30-60 min) or under microwave conditions in shorter duration (5 min).

Use of N-acyl derivatives of aminoalcohols for the manufacture of a medicament for the treatment of pathologies involving mast cells

N-acyl-derivatives of amino alcohols suitable for the therapeutic treatment of pathologies characterized by degranulation of mast cells caused by a neurogen and/or immunogenic hyperstimulation.